[HTML][HTML] S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates
…, A Huang, D Luo, C Zhao, F Yang, JB Han… - Nature …, 2021 - nature.com
SARS-CoV-2 is the underlying cause for the COVID-19 pandemic. Like most enveloped
RNA viruses, SARS-CoV-2 uses a homotrimeric surface antigen to gain entry into host cells. …
RNA viruses, SARS-CoV-2 uses a homotrimeric surface antigen to gain entry into host cells. …
[HTML][HTML] Specific inhibition of the NLRP3 inflammasome suppresses immune overactivation and alleviates COVID-19 like pathology in mice
J Zeng, X Xie, XL Feng, L Xu, JB Han, D Yu, QC Zou… - …, 2022 - thelancet.com
Background The Coronavirus Disease 2019 (COVID-19) pandemic has been a great threat
to global public health since 2020. Although the advance on vaccine development has been …
to global public health since 2020. Although the advance on vaccine development has been …
A tandem-repeat dimeric RBD protein-based covid-19 vaccine zf2001 protects mice and nonhuman primates
Y An, S Li, X Jin, J Han, K Xu, S Xu, Y Han… - Emerging microbes & …, 2022 - Taylor & Francis
Safe, efficacious, and deployable vaccines are urgently needed to control COVID-19 in the
large-scale vaccination campaigns. We report here the preclinical studies of an approved …
large-scale vaccination campaigns. We report here the preclinical studies of an approved …
[HTML][HTML] Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2
…, Y Lin, H Huang, F Zhao, S Zhang, Y Gao, JB Han… - Cell Research, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global crisis,
urgently necessitating the development of safe, efficacious, convenient-to-store, and low-…
urgently necessitating the development of safe, efficacious, convenient-to-store, and low-…
[HTML][HTML] COVID-19-like symptoms observed in Chinese tree shrews infected with SARS-CoV-2
…, YL Yao, RH Luo, XL Feng, HR Cai, JB Han… - Zoological …, 2020 - ncbi.nlm.nih.gov
The coronavirus disease 2019 (COVID-19) pandemic continues to pose a global threat to
the human population. Identifying animal species susceptible to infection with the SARS-CoV-2…
the human population. Identifying animal species susceptible to infection with the SARS-CoV-2…
[HTML][HTML] Delayed severe cytokine storm and immune cell infiltration in SARS-CoV-2-infected aged Chinese rhesus macaques
TZ Song, HY Zheng, JB Han, L Jin, X Yang… - Zoological …, 2020 - ncbi.nlm.nih.gov
As of June 2020, Coronavirus Disease 2019 (COVID-19) has killed an estimated 440 000
people worldwide, 74% of whom were aged≥ 65 years, making age the most significant risk …
people worldwide, 74% of whom were aged≥ 65 years, making age the most significant risk …
[HTML][HTML] SARS-CoV-2 Spike protein S2 subunit modulates γ-secretase and enhances amyloid-β production in COVID-19 neuropathy
…, QC Zou, X Xie, L Xu, XL Feng, X Li, JB Han… - Cell Discovery, 2022 - nature.com
Dear Editor, SARS-CoV-2-induced multi-lineage neural cell dysregulation has been documented
1. SARS-CoV-2 infection elevates neuroinflammation 2, alters brain structure 3 leads …
1. SARS-CoV-2 infection elevates neuroinflammation 2, alters brain structure 3 leads …
[HTML][HTML] Emerging SARS-CoV-2 B. 1.621/Mu variant is prominently resistant to inactivated vaccine-elicited antibodies
X Xie, JB Han, G Ma, XL Feng, X Li, QC Zou… - Zoological …, 2021 - ncbi.nlm.nih.gov
Although it first appeared almost two years ago, the COVID-19 pandemic continues to have
an impact on a global scale, in part due to newly emerging SARS-CoV-2 variants such as …
an impact on a global scale, in part due to newly emerging SARS-CoV-2 variants such as …
[HTML][HTML] Single-nucleus transcriptomic profiling of multiple organs in a rhesus macaque model of SARS-CoV-2 infection
…, W Ma, TZ Song, Z Wu, Z Liu, Z Hu, JB Han… - Zoological …, 2022 - ncbi.nlm.nih.gov
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes
diverse clinical manifestations and tissue injuries in multiple organs. However, cellular and …
diverse clinical manifestations and tissue injuries in multiple organs. However, cellular and …
[PDF][PDF] A recombinant receptor-binding domain in trimeric form generates protective immunity against SARS-CoV-2 infection in nonhuman primates
L Yang, D Tian, J Han, W Fan, Y Zhang, Y Li, W Sun… - The Innovation, 2021 - cell.com
A safe and effective vaccine is critical to combat the COVID-19 pandemic. Here, we developed
a trimeric SARS-CoV-2 receptor-binding domain (RBD) subunit vaccine candidate that …
a trimeric SARS-CoV-2 receptor-binding domain (RBD) subunit vaccine candidate that …