Human uterine leiomyomas (ULMs) are the most common neoplasms of women. Many
genes are dysregulated in ULMs and some of this dysregulation may be due to abnormal …

Endometriosis is a chronic disease that affects millions of reproductive-age women. Despite
the destructive and invasive nature of endometrioses, most cases are perpetually benign or …

BACKGROUND Uterine leiomyoma is the most common benign tumor in women and is
thought to arise from the clonal expansion of a single myometrial smooth muscle cell …

BACKGROUND Adenomyosis, characterized by the presence of islands of endometrial tissue
surrounded by hypertrophic smooth muscle cells within the myometrium, is one of the most …

Molecular pathogenesis of high‐grade serous ovarian carcinoma (HG‐SOC) is poorly
understood. Recent recognition of HG‐SOC precursor lesions, defined as serous tubal …

Nearly 70% of Uterine fibroid (UF) tumors are driven by recurrent MED12 hotspot mutations.
Unfortunately, no cellular models could be generated because the mutant cells have lower …

Recent identification of somatic MED12 mutations in most uterine leiomyomas brings a new
venue for the study of the tumorigenesis of leiomyomas. We are particularly interested in the …

The AT-hook transcription factor HMGA2 is an oncogene involved in the tumorigenesis of
many malignant neoplasms. HMGA2 overexpression is common in both early and late-stage …

High-mobility group A2 (HMGA2) is commonly overexpressed in large leiomyomas. HMGA2
is an important regulator of cell growth, differentiation, apoptosis, and transformation. As a …

Fatty acids are an important source of energy and a key component of phospholipids in
membranes and organelles. Saturated fatty acids (SFAs) are converted into unsaturated fatty …