Inflammatory caspases (caspases 1, 4, 5 and 11) are activated in response to microbial
infection and danger signals. When activated, they cleave mouse and human gasdermin D (…

Inflammasomes elicit host defense inside cells by activating caspase-1 for cytokine maturation
and cell death. AIM2 and NLRP3 are representative sensor proteins in two major families …

Cytosolic sensing of pathogens and damage by myeloid and barrier epithelial cells
assembles large complexes called inflammasomes, which activate inflammatory caspases to …

The interleukin-1 (IL-1) family cytokines are cytosolic proteins that exhibit inflammatory activity
upon release into the extracellular space. These factors are released following various …

As organelles of the innate immune system, inflammasomes activate caspase-1 and other
inflammatory caspases that cleave gasdermin D (GSDMD). Caspase-1 also cleaves inactive …

Dendritic cells (DCs) use pattern recognition receptors to detect microorganisms and
activate protective immunity. These cells and receptors are thought to operate in an all-or-nothing …

The NLR family apoptosis inhibitory proteins (NAIPs) bind conserved bacterial ligands, such
as the bacterial rod protein PrgJ, and recruit NLR family CARD-containing protein 4 (NLRC4…

Sluggish transport kinetics and rapid dendrite growth are considered the main obstacles that
impair the performance of Zn metal batteries. This work has developed a unique strategy of …

Gasdermins mediate inflammatory cell death after cleavage by caspases or other, unknown
enzymes. The cleaved N-terminal fragments bind to acidic membrane lipids to form pores, …

The SAGA (Spt–Ada–Gcn5 acetyltransferase) complex is an important chromatin modifying
complex that can both acetylate and deubiquitinate histones. Sgf29 is a novel component of …