Oncolytic viruses (OV) are a class of antitumor agents that selectively kill tumor cells while
sparing normal cells. Oncolytic herpes simplex virus (oHSV) has been investigated in clinical …

Glioblastoma (World Health Organization grade IV) is an aggressive adult brain tumor that
is inevitably fatal despite surgery, radiation, and chemotherapy. Treatment failures are …

Purpose: Emergence of mismatch repair (MMR) deficiency is a frequent mechanism of
acquired resistance to the alkylating chemotherapeutic temozolomide (TMZ) in gliomas. Poly(ADP…

Purpose: Previous studies have shown that the PI3K/Akt/mTOR pathway is activated in up to
70% of breast cancer brain metastases, but there are no approved agents for affected …

Background Recurrence after radiation therapy is nearly universal for glioblastomas, the
most common form of adult brain cancer. The study aims to define clinically pertinent …

Cancer-associated fibroblasts (CAFs) are activated fibroblasts constituting the major stromal
components in many types of cancer. CAFs contribute to hallmarks of cancer such as …

Precision medicine in oncology leverages clinical observations of exceptional response.
Toward an understanding of the molecular features that define this response, we applied an …

Glioblastoma multiforme (GBM) is among the most aggressive, treatment-resistant cancers,
and despite standard of care surgery, radiation and chemotherapy, is invariably fatal. GBM is …

Background: Clinical success of poly(ADP-ribose) polymerase inhibitors (PARPi) has been
limited to repair-deficient cancers and by resistance. Oncolytic herpes simplex viruses (…

In response to a variety of cellular stresses, poly(ADP-ribose) polymerase 1 (PARP1) has
vital roles in orchestrating DNA damage repair and preserving genomic integrity. Clinical …