Purpose: Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated
protein (Cas) has recently been adapted to enable efficient editing of the …

Many clinical trials using gene therapy have shown significant therapeutic benefits and
exceptional safety records. Increasing evidence is verifying the long sought-after promise that …

Inherited retinal diseases (IRDs) comprise a heterogeneous group of genetic disorders affecting
the retina. Caused by mutations in over 300 genes, IRDs result in visual impairment due …

Genetic medicine is offering hope as new therapies are emerging for many previously untreatable
diseases. The eye is at the forefront of these advances, as exemplified by the approval …

Aberrant growth of blood vessels (neovascularization) is a key feature of severe eye diseases
that can cause legal blindness, including neovascular age-related macular degeneration (…

Ferroptosis contributes to the pathogenesis of atrial fibrillation (AF), although the
mechanisms are still largely uncovered. The current study was designed to explore the …

Purpose of Review Diabetic retinopathy (DR), a leading cause of visual impairment in the
developed country, is characterized by vascular lesions and neuronal damage of the retina. …

Adeno-associated virus (AAV) has emerged as a pivotal delivery tool in clinical gene therapy
owing to its minimal pathogenicity and ability to establish long-term gene expression in …

Diabetic retinopathy (DR), a chronic and progressive complication of diabetes mellitus, is a
sight-threatening disease characterized in the early stages by neuronal and vascular …

Polydatin has attracted much attention as a potential cardioprotective agent against
ischemic heart disease and diabetic cardiomyopathy. However, the effect and mechanism of …