Clonal dynamics of native haematopoiesis
J Sun, A Ramos, B Chapman, JB Johnnidis, L Le… - Nature, 2014 - nature.com
It is currently thought that life-long blood cell production is driven by the action of a small
number of multipotent haematopoietic stem cells. Evidence supporting this view has been …
number of multipotent haematopoietic stem cells. Evidence supporting this view has been …
Clonal analysis of lineage fate in native haematopoiesis
…, CS Weinreb, R Panero, SH Patel, M Jankovic, J Sun… - Nature, 2018 - nature.com
Haematopoiesis, the process of mature blood and immune cell production, is functionally
organized as a hierarchy, with self-renewing haematopoietic stem cells and multipotent …
organized as a hierarchy, with self-renewing haematopoietic stem cells and multipotent …
[PDF][PDF] Large-scale multiplexed mosaic CRISPR perturbation in the whole organism
Here, we report inducible mosaic animal for perturbation (iMAP), a transgenic platform
enabling in situ CRISPR targeting of at least 100 genes in parallel throughout the mouse body. …
enabling in situ CRISPR targeting of at least 100 genes in parallel throughout the mouse body. …
A genetic screen identifies an LKB1–MARK signalling axis controlling the Hippo–YAP pathway
The Hippo–YAP pathway is an emerging signalling cascade involved in the regulation of stem
cell activity and organ size. To identify components of this pathway, we performed an RNAi…
cell activity and organ size. To identify components of this pathway, we performed an RNAi…
[HTML][HTML] Non-invasive lung cancer diagnosis and prognosis based on multi-analyte liquid biopsy
K Chen, J Sun, H Zhao, R Jiang, J Zheng, Z Li, J Peng… - Molecular cancer, 2021 - Springer
Lung cancer (LC) is the leading cause of death in many countries including China. The stage
at which LC is diagnosed has a significant impact on prognosis. However, timely detection …
at which LC is diagnosed has a significant impact on prognosis. However, timely detection …
[HTML][HTML] Mouse cofactor of BRCA1 (Cobra1) is required for early embryogenesis
Background Negative elongation factor (NELF) is a four-subunit protein complex conserved
from Drosophila to humans. In vitro biochemical and tissue culture-based studies have …
from Drosophila to humans. In vitro biochemical and tissue culture-based studies have …
[HTML][HTML] Human negative elongation factor activates transcription and regulates alternative transcription initiation
J Sun, R Li - Journal of biological chemistry, 2010 - ASBMB
The human negative elongation factor (NELF) is a four-subunit protein complex that inhibits
the movement of RNA polymerase II (RNAPII) at an early elongation stage in vitro. NELF-…
the movement of RNA polymerase II (RNAPII) at an early elongation stage in vitro. NELF-…
Design and performance test of a 20-kV DC superconducting fault current limiter
J Sun, J Du, Y Li, S Mo, Y Cai… - IEEE Transactions on …, 2020 - ieeexplore.ieee.org
A resistive-type dc superconducting fault current limiter (SFCL) is developed for the fault current
limiting at the Suzhou Nami substation. The rated voltage and current are 20 kV and 400 …
limiting at the Suzhou Nami substation. The rated voltage and current are 20 kV and 400 …
Attenuation of estrogen receptor α-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor
SE Aiyar, J Sun, AL Blair, CA Moskaluk… - Genes & …, 2004 - genesdev.cshlp.org
Estrogen receptor α (ERα) signaling is paramount for normal mammary gland development
and function and the repression of breast cancer. ERα function in gene regulation is …
and function and the repression of breast cancer. ERα function in gene regulation is …
Novel soliton molecules and interaction wave solutions in a (2+ 1)-dimensional Sawada–Kotera equation: a multi-linear variable separation method
J Sun, Z Li, H An, H Zhu - Nonlinear Dynamics, 2023 - Springer
The multi-linear variable separation method has been always considered as an effective tool
to solve nonlinear physical models. In this paper, by introducing three new types of variable …
to solve nonlinear physical models. In this paper, by introducing three new types of variable …