Transcription factors (TFs) and their specific interactions with targets are crucial for specifying
gene-expression programs. To gain insights into the transcriptional regulatory networks in …

Congenital heart disease (CHD) is the most frequent birth defect, affecting 0.8% of live births
1 . Many cases occur sporadically and impair reproductive fitness, suggesting a role for de …

Embryonic stem (ES) cells are unique in their ability to self-renew indefinitely and maintain
pluripotency. These properties require transcription factors that specify the gene expression …

The dominant effect of transcription factors in imparting expanded potency is best
exemplified by the reprogramming of fibroblasts to pluripotent cells using retrovirus-mediated …

Somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) with the
introduction of Oct4, Sox2, Klf4, and c-Myc. Among these four factors, Oct4 is critical in inducing …

The derivation of human ES cells (hESCs) from human blastocysts represents one of the
milestones in stem cell biology 1 . The full potential of hESCs in research and clinical …

Rationale: Yes-associated protein (YAP), the terminal effector of the Hippo signaling
pathway, is crucial for regulating embryonic cardiomyocyte proliferation. Objective: We …

Porous carbon fibers (pores of: 0.1–3 μm in diameter) and carbon nanofibers (∼100 nm in
diameter) were prepared from polyacrylonitrile/polymethyl methacrylate (PAN/PMMA) blend …

Polyhexamethylene guanidine hydrochloride and polyhexamethylene biguanidine hydrochloride
were polycondensated in the melt of monomers. The intrinsic viscosity and M ̄ n were …

Dominant mutations in sarcomere proteins such as the myosin heavy chains (MHC) are the
leading genetic causes of human hypertrophic cardiomyopathy (HCM) and dilated …