[HTML][HTML] SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19

…, X Zhao, Y Xie, Y Yang, S Zhang, Z Fan, J Dong… - Journal of hematology & …, 2020 - Springer
Background Critically ill patients diagnosed with COVID-19 may develop a pro-thrombotic
state that places them at a dramatically increased lethal risk. Although platelet activation is …

[HTML][HTML] Current understanding of the pathophysiology of myocardial fibrosis and its quantitative assessment in heart failure

T Liu, D Song, J Dong, P Zhu, J Liu, W Liu, X Ma… - Frontiers in …, 2017 - frontiersin.org
Myocardial fibrosis is an important part of cardiac remodeling that leads to heart failure and
death. Myocardial fibrosis results from increased myofibroblast activity and excessive …

Atrial fibrillation prevalence, awareness and management in a nationwide survey of adults in China

…, S Wu, X Guang, X Zhou, H Lin, X Cheng, J Dong… - Heart, 2021 - heart.bmj.com
Objective To determine AF prevalence and gaps in atrial fibrillation (AF) awareness and
management in China. Methods We conducted a community-based survey of 47 841 adults (…

Epidemiology of Cardiovascular Disease in China and Opportunities for Improvement: JACC International

X Du, A Patel, CS Anderson, J Dong, C Ma - Journal of the American …, 2019 - jacc.org
The burden of cardiovascular (CV) disease is very high in China, due to highly prevalent
and poorly controlled risk factors resulting from changing sociodemographic structure and …

[HTML][HTML] Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent

…, H Liu, G Jiang, Z Cheng, S Wang, J Dong… - Nature …, 2017 - nature.com
Interleukin-12 (IL-12) has emerged as one of the most potent agents for anti-tumor immunotherapy.
However, potentially lethal toxicity associated with systemic administration of IL-12 …

Is atrial fibrillation a preventable disease?

X Du, J Dong, C Ma - Journal of the American College of Cardiology, 2017 - jacc.org
Atrial fibrillation (AF) is an increasing burden worldwide. However, AF prevention has not
been emphasized enough in clinical practice or guidelines. In this paper, the authors review …

[HTML][HTML] Paracrine action of mesenchymal stem cells revealed by single cell gene profiling in infarcted murine hearts

…, F Wang, X Liu, M Shang, S Nie, N Liu, X Du, J Dong… - PloS one, 2015 - journals.plos.org
Background Mesenchymal stem cells (MSCs) have been recently demonstrated as a
promising stem cell type to rescue damaged myocardium after acute infarction. One of the most …

Sex differences in primary and secondary prevention of cardiovascular disease in China

…, X Zhou, H Lin, X Cheng, CS Anderson, J Dong… - Circulation, 2020 - Am Heart Assoc
Background: Despite improvements in diagnostic and therapeutic interventions to combat
cardiovascular disease (CVD) in recent decades, there are significant ongoing access gaps …

Pulmonary artery denervation significantly increases 6-min walk distance for patients with combined pre-and post-capillary pulmonary hypertension associated with …

…, DJ Xie, J Kan, W Yu, XB Li, T Xu, Y Gu, J Dong… - Cardiovascular …, 2019 - jacc.org
Objectives The authors sought to assess the benefits of pulmonary artery denervation (PADN)
among combined pre- and post-capillary pulmonary hypertension (CpcPH) patients in a …

Achievement of pulmonary vein isolation in patients undergoing circumferential pulmonary vein ablation: a randomized comparison between two different isolation …

X Liu, J Dong, HE Mavrakis, F Hu… - Journal of …, 2006 - Wiley Online Library
Introduction: Circumferential pulmonary vein ablation (CPVA) with the endpoint of pulmonary
vein (PV) isolation has been developed as an effective therapy for atrial fibrillation (AF). …