Differential transcription of identical DNA sequences leads to distinct tissue lineages and
then multiple cell types within a lineage, an epigenetic process central to progenitor and stem …

The lung microvasculature is essential for gas exchange and commonly considered
homogeneous. We show that VEGFA from the epithelium is required for a distinct endothelial cell (…

Epigenetic modifiers frequently harbor loss-of-function mutations in lung cancer, but their
tumor-suppressive roles are poorly characterized. Histone methyltransferase KMT2D (a …

Mammalian organs, including the lung and kidney, often adopt a branched structure to
achieve high efficiency and capacity of their physiological functions. Formation of a functional …

… Jichao Chen … Ostrin, Jichao Chen; The development and plasticity of alveolar type 1
cells. Development 1 January 2016; 143 (1): 54–65. doi: https://doi.org/10.1242/dev.130005 …

Natural products (NPs) have played a key role in drug discovery and are still a prolific source
of novel lead compounds or pharmacophores for medicinal chemistry. Pharmacological …

A Cu‐catalyzed regio‐, diastereo‐, and enantioselective carboboration of 1,1‐bisboryl‐1,3‐butadiene
is developed to generate enantioenriched 3,6′‐bisboryl‐anti‐1,2‐oxaborinan‐3‐…

Abstract Development of resistance to chemotherapy in cancer continues to be a major
challenge in cancer management. Ferroptosis, a unique type of cell death, is mechanistically and …

This study addresses one genetic regulatory mechanism that establishes the distinct
identities of rod and cone photoreceptors. Previous work has shown that mutations in either …

Divergent N 6 -methyladenosine (m 6 A) modifications are dynamic and reversible
posttranscriptional RNA modifications that are mediated by m 6 A regulators or m 6 A RNA …