In the fatal disease—amyotrophic lateral sclerosis (ALS)—upper (corticospinal) motor
neurons (MNs) and lower somatic MNs, which innervate voluntary muscles, degenerate. …

Spinal motor axons traverse large distances to innervate target muscles, thus requiring local
control of cellular events for proper functioning. To interrogate axon-specific processes we …

The cytokine transforming growth factor-β (TGF-β) regulates the development and homeostasis
of several tissue-resident macrophage populations, including microglia. TGF-β is not …

Somatic motor neurons are selectively vulnerable in spinal muscular atrophy (SMA), which
is caused by a deficiency of the ubiquitously expressed survival of motor neuron protein. …

Neuromuscular junctions are primary pathological targets in the lethal motor neuron
diseases spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS). Synaptic …

Recent studies in neuron‐glial metabolic coupling have shown that, in the CNS, astrocytes
and oligodendrocytes support neurons with energy‐rich lactate/pyruvate via …

Endurance exercise promotes skeletal muscle vascularization, oxidative metabolism, fiber-type
switching, and neuromuscular junction integrity. Importantly, the metabolic and …

Oculomotor neurons, which regulate eye movement, are resilient to degeneration in the
lethal motor neuron disease amyotrophic lateral sclerosis (ALS). It would be highly …

Cytosolic aggregation of the nuclear protein TDP-43 is associated with many
neurodegenerative diseases, but the triggers for TDP-43 aggregation are still debated. Here, we …

Single-cell mRNA sequencing can dissect heterogeneous cell populations as it can identify
cell types and cellular states based on their unique transcriptional signatures. We use …