Helenius and colleagues proposed over 20‐years ago a paradigm‐shifting model for how
chaperone binding in the endoplasmic reticulum was mediated and controlled for a new type …

Dietary restriction is a robust means of extending adult lifespan and postponing age-related
disease in many species, including yeast, nematode worms, flies and rodents 1 , 2 . Studies …

The endoplasmic reticulum (ER) is organized in part by adapter proteins that nucleate the
formation of large protein complexes. Tetratricopeptide repeats (TPR) are well studied protein …

The endoplasmic reticulum (ER) is a complex, multifunctional organelle comprised of a
continuous membrane and lumen that is organized into a number of functional regions. It plays …

Protein glycosylation plays essential roles in protein structure, stability, and activity such as
cell adhesion. The cadherin superfamily of adhesion molecules carry O-linked mannose …

Protein folding, quality control, maturation, and trafficking are essential processes for proper
cellular homeostasis. Around one-third of the human proteome is targeted to the …

Protein glycosylation plays essential roles in protein structure, stability and activity such as
cell adhesion. The cadherin superfamily of adhesion molecules carry O-linked mannose …

… There are sex differences in rodent models of addiction that are comparable to what is
reported in the clinical literature (Jill B [7]). Female rats acquire cocaine self-administration more …

Mitochondrial myopathy, lactic acidosis and sideroblastic anemia (MLASA) is a rare mitochondrial
disorder that has previously been associated with mutations in PUS1 and YARS2. In …

… Buchan PhD, D(ABMM) a , , Mary Beth Graham MD b , Jill Lindmair-Snell RN, MSN, CIC d
, Jennifer Arvan BSN, RN d , Nathan A. Ledeboer PhD, D(ABMM) a , Rahul Nanchal MD c , L. …