Autism is a heterogeneous neurodevelopmental disorder of unknown aetiology that affects
1 in 100–150 individuals. Diagnosis is based on three categories of behavioural criteria: …

Background SHANK3 is a protein in the core of the postsynaptic density (PSD) and has a
critical role in recruiting many key functional elements to the PSD and to the synapse, including …

Autism is diagnosed by three major symptom categories: unusual reciprocal social interactions,
impaired communication, and repetitive behaviors with restricted interests. Direct social …

Autism is a neurodevelopmental disorder characterized by abnormal reciprocal social
interactions, communication deficits, and repetitive behaviors with restricted interests. BTBR T+ tf/J …

Mutations in the synaptic scaffolding protein gene SHANK3 are strongly implicated in autism
and Phelan–McDermid 22q13 deletion syndrome. The precise location of the mutation …

Cerebellar dysfunction has been demonstrated in autism spectrum disorders (ASDs);
however, the circuits underlying cerebellar contributions to ASD-relevant behaviors remain …

Neurodevelopmental disorders such as autism and fragile X syndrome were long thought to
be medically untreatable, on the assumption that brain dysfunctions were immutably …

Fragile X Syndrome (FXS) is a commonly inherited form of intellectual disability and one of
the leading genetic causes for autism spectrum disorder. Clinical symptoms of FXS can …

Autism is a neurodevelopmental disorder characterized by aberrant reciprocal social interactions,
impaired communication, and repetitive behaviors. While the etiology remains unclear, …

The chromatin remodeling gene CHD8 represents a central node in neurodevelopmental
gene networks implicated in autism. We examined the impact of germline heterozygous …