The human and mouse genomes contain instructions that specify RNAs and proteins and
govern the timing, magnitude, and cellular context of their production. To better delineate these …

INTRODUCTION Strong genetic associations have been found for a number of psychiatric
disorders. However, understanding the underlying molecular mechanisms remains …

The Encyclopedia of DNA Elements (ENCODE) consortium aims to identify all functional
elements in the human genome including transcripts, transcriptional regulatory regions, along …

Large-scale whole-genome sequencing studies have enabled the analysis of rare variants (RVs)
associated with complex phenotypes. Commonly used RV association tests have …

Understanding the regulatory landscape of the human genome is a long-standing objective
of modern biology. Using the reference-free alignment across 241 mammalian genomes …

Dipeptide repeat (DPR) proteins are toxic in various models of FTD/ALS with GGGGCC (G 4
C 2 ) repeat expansion. However, it is unclear whether nuclear G 4 C 2 RNA foci also …

Efforts to reduce controlled-substance abuse by anesthesiologists have focused on education
and tighter regulation of controlled substances. However, the efficacy of these approaches …

Mycobacterium bovis Bacillus Calmette-Guérin (BCG) use in the treatment of bladder cancer
was first reported in 1976, but the mechanism of the induced antitumor activity has still not …

CRISPR is widely used to disrupt gene function by inducing small insertions and deletions.
Here, we show that some single-guide RNAs (sgRNAs) can induce exon skipping or large …

Large biobank-scale whole genome sequencing (WGS) studies are rapidly identifying a
multitude of coding and non-coding variants. They provide an unprecedented resource for …