De novo 3D models of SARS-CoV-2 RNA elements from consensus experimental secondary structures
…, W Kladwang, IN Zheludev, J Townley… - Nucleic acids …, 2021 - academic.oup.com
The rapid spread of COVID-19 is motivating development of antivirals targeting conserved
SARS-CoV-2 molecular machinery. The SARS-CoV-2 genome includes conserved RNA …
SARS-CoV-2 molecular machinery. The SARS-CoV-2 genome includes conserved RNA …
[HTML][HTML] Community science designed ribosomes with beneficial phenotypes
…, Y Kim, J Anderson-Lee, E Fisker, J Townley… - Nature …, 2023 - nature.com
Functional design of ribosomes with mutant ribosomal RNA (rRNA) can expand
opportunities for understanding molecular translation, building cells from the bottom-up, and …
opportunities for understanding molecular translation, building cells from the bottom-up, and …
Roux‐en‐Y gastric bypass, gastric banding, or sleeve gastrectomy for severe obesity: Baseline data from the By‐Band‐Sleeve randomized controlled trial
…, R Mullett, J Rojkova, N Salter, PB Sardo, J Townley… - …, 2023 - Wiley Online Library
Objective This paper reports the study design, participant characteristics, and recruitment
results of By‐Band‐Sleeve, which investigated the clinical and cost‐effectiveness of gastric …
results of By‐Band‐Sleeve, which investigated the clinical and cost‐effectiveness of gastric …
Minimization of the E. coli ribosome, aided and optimized by community science
T Tangpradabkul, M Palo, J Townley… - Nucleic Acids …, 2024 - academic.oup.com
The ribosome is a ribonucleoprotein complex found in all domains of life. Its role is to
catalyze protein synthesis, the messenger RNA (mRNA)-templated formation of amide bonds …
catalyze protein synthesis, the messenger RNA (mRNA)-templated formation of amide bonds …
De novo 3D models of SARS-CoV-2 RNA elements and small-molecule-binding RNAs to aid drug discovery
…, J Chacon, W Kladwang, IN Zheludev, J Townley… - BioRxiv, 2020 - biorxiv.org
The rapid spread of COVID-19 motivates development of antivirals targeting conserved
molecular machinery of the SARS-CoV-2 virus. The SARS-CoV-2 genome includes conserved …
molecular machinery of the SARS-CoV-2 virus. The SARS-CoV-2 genome includes conserved …
Daily Duration of Eating for Children and Adolescents: A Systematic Review and Meta-Analysis
Time-limited eating is a dietary intervention whereby eating is limited to a specific window of
time during the day. The usual eating windows of adults, and how these can be manipulated …
time during the day. The usual eating windows of adults, and how these can be manipulated …
Medication following bariatric surgery for type 2 diabetes mellitus (BY-PLUS) study: rationale and design of a randomised controlled study
Introduction Bariatric surgery is an effective method of controlling glycaemia in patients with
type 2 diabetes mellitus (T2DM) and obesity. Long-term studies suggest that although …
type 2 diabetes mellitus (T2DM) and obesity. Long-term studies suggest that although …
Evidence of an unusual Poly (A) RNA signature detected by high-throughput chemical mapping
…, E Fisker, M Zada, M Wiley, J Townley… - Biochemistry, 2020 - ACS Publications
Homopolymeric adenosine RNA plays numerous roles in both cells and noncellular genetic
material. We report herein an unusual poly(A) signature in chemical mapping data …
material. We report herein an unusual poly(A) signature in chemical mapping data …
Ribonanza: deep learning of RNA structure through dual crowdsourcing
S He, R Huang, J Townley, RC Kretsch, TG Karagianes… - bioRxiv, 2024 - biorxiv.org
Prediction of RNA structure from sequence remains an unsolved problem, and progress has
been slowed by a paucity of experimental data. Here, we present Ribonanza, a dataset of …
been slowed by a paucity of experimental data. Here, we present Ribonanza, a dataset of …
[HTML][HTML] Protocol: Medication following bariatric surgery for type 2 diabetes mellitus (BY-PLUS) study: rationale and design of a randomised controlled study
… Alexis Sudlow, corresponding author 1 Alexander Dimitri Miras, 2, 3 Ricardo Vitor Cohen,
4, 5 Hassan Kahal, 6 Jill Townley, 7 Helen Heneghan, 8 Carel Le Roux, 9 and Dimitri J …
4, 5 Hassan Kahal, 6 Jill Townley, 7 Helen Heneghan, 8 Carel Le Roux, 9 and Dimitri J …