p53 is a tumor suppressor protein whose function is frequently lost in cancers through
missense mutations within the Tp53 gene. This results in the expression of point-mutated p53 …

Since it has become clear that adhesion receptors are trafficked through the endosomal
pathway and that this can influence their function, much effort has been invested in obtaining …

Inhibitors of α v β 3 and α v β 5 integrin have entered clinical trials as antiangiogenic agents
for cancer treatment but generally have been unsuccessful. Here we present in vivo …

In about half of all human cancers, the tumor suppressor p53 protein is either lost or mutated,
frequently resulting in the expression of a transcriptionally inactive mutant p53 protein. …

Here, we report a direct interaction between the β1 integrin cytoplasmic tail and Rab25, a
GTPase that has been linked to tumor aggressiveness and metastasis. Rab25 promotes a …

Here we show that blocking the adhesive function of αvβ3 integrin with soluble RGD ligands,
such as osteopontin or cilengitide, promoted association of Rab-coupling protein (RCP) …

In the late 1980s and early 1990s, the observation that certain integrin heterodimers are
continually internalized from the plasma membrane into endosomal compartments and …

Integrin adhesion receptors are essential for the normal function of most multicellular
organisms, and defective integrin activation or integrin signaling is associated with an array of …

Here we show that Rab25 permits the sorting of ligand-occupied, active-conformation α5β1
integrin to late endosomes/lysosomes. Photoactivation and biochemical approaches show …

The past five years have seen a steady accumulation of data reinforcing the view that Rab-regulated
recycling pathways contribute to cell migration. In particular, detailed descriptions …