[HTML][HTML] Macrocyclization of an all-d linear α-helical peptide imparts cellular permeability
…, HYK Kaan, A Chandramohan, JH Wong… - Chemical …, 2020 - pubs.rsc.org
Peptide-based molecules hold great potential as targeted inhibitors of intracellular protein–protein
interactions (PPIs). Indeed, the vast diversity of chemical space conferred through …
interactions (PPIs). Indeed, the vast diversity of chemical space conferred through …
[HTML][HTML] A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein–protein interactions identifies a novel putative Mdm2 …
Background Protein–protein interactions (PPIs) are fundamental to the growth and survival
of cells and serve as excellent targets to develop inhibitors of biological processes such as …
of cells and serve as excellent targets to develop inhibitors of biological processes such as …
[HTML][HTML] TORC1 regulates the transcriptional response to glucose and developmental cycle via the Tap42-Sit4-Rrd1/2 pathway in Saccharomyces cerevisiae
M Alfatah, JH Wong, VG Krishnan, YC Lee, QF Sin… - BMC biology, 2021 - Springer
Background Target of Rapamycin Complex 1 (TORC1) is a highly conserved eukaryotic
protein complex that couples the presence of growth factors and nutrients in the environment …
protein complex that couples the presence of growth factors and nutrients in the environment …
[PDF][PDF] Metabolism of glucose activates TORC1 through multiple mechanisms in Saccharomyces cerevisiae
…, CJH Goh, TYN Cheng, Y Zhang, A Naaz, JH Wong… - Cell Reports, 2023 - cell.com
Target of Rapamycin Complex 1 (TORC1) is a conserved eukaryotic protein complex that links
the presence of nutrients with cell growth. In Saccharomyces cerevisiae, TORC1 activity is …
the presence of nutrients with cell growth. In Saccharomyces cerevisiae, TORC1 activity is …
Identification of pathways modulating vemurafenib resistance in melanoma cells via a genome-wide CRISPR/Cas9 screen
CJH Goh, JH Wong, C El Farran, BX Tan, CR Coffill… - G3, 2021 - academic.oup.com
Vemurafenib is a BRAF kinase inhibitor (BRAFi) that is used to treat melanoma patients
harboring the constitutively active BRAF-V600E mutation. However, after a few months of …
harboring the constitutively active BRAF-V600E mutation. However, after a few months of …
[HTML][HTML] Diethyl phthalate (DEP) perturbs nitrogen metabolism in Saccharomyces cerevisiae
Phthalates are ubiquitously used as plasticizers in various consumer care products. Diethyl
phthalate (DEP), one of the main phthalates, elicits developmental and reproductive …
phthalate (DEP), one of the main phthalates, elicits developmental and reproductive …
[HTML][HTML] Genome-wide analysis of mRNAs associated with mouse peroxisomes
…, M Kremenskoy, AO Batagov, A Preuss, JH Wong… - BMC genomics, 2016 - Springer
Background RNA is often targeted to be localized to the specific subcellular compartments.
Specific localization of mRNA is believed to be an important mechanism for targeting their …
Specific localization of mRNA is believed to be an important mechanism for targeting their …
[HTML][HTML] Chemogenomic profiling in yeast reveals antifungal mode-of-action of polyene macrolactam auroramycin
In this study, we report antifungal activity of auroramycin against Candida albicans, Candida
tropicalis, and Cryptococcus neoformans. Auroramycin, a potent antimicrobial doubly …
tropicalis, and Cryptococcus neoformans. Auroramycin, a potent antimicrobial doubly …
Chemical-genetic interaction landscape of mono-(2-ethylhexyl)-phthalate using chemogenomic profiling in yeast
Integration of chemical-genetic interaction data with biological functions provides a mechanistic
understanding of how toxic compounds affect cells. Mono-(2-ethylhexyl)-phthalate (…
understanding of how toxic compounds affect cells. Mono-(2-ethylhexyl)-phthalate (…
[HTML][HTML] Hypoculoside, a sphingoid base-like compound from Acremonium disrupts the membrane integrity of yeast cells
M Alfatah, JH Wong, CE Nge, KW Kong, KN Low… - Scientific Reports, 2019 - nature.com
We have isolated Hypoculoside, a new glycosidic amino alcohol lipid from the fungus
Acremonium sp. F2434 belonging to the order Hypocreales and determined its structure by 2D-…
Acremonium sp. F2434 belonging to the order Hypocreales and determined its structure by 2D-…