[HTML][HTML] Macrocyclization of an all-d linear α-helical peptide imparts cellular permeability

…, HYK Kaan, A Chandramohan, JH Wong… - Chemical …, 2020 - pubs.rsc.org
Peptide-based molecules hold great potential as targeted inhibitors of intracellular protein–protein
interactions (PPIs). Indeed, the vast diversity of chemical space conferred through …

[HTML][HTML] A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein–protein interactions identifies a novel putative Mdm2 …

JH Wong, M Alfatah, MF Sin, HM Sim, CS Verma… - BMC biology, 2017 - Springer
Background Protein–protein interactions (PPIs) are fundamental to the growth and survival
of cells and serve as excellent targets to develop inhibitors of biological processes such as …

[HTML][HTML] TORC1 regulates the transcriptional response to glucose and developmental cycle via the Tap42-Sit4-Rrd1/2 pathway in Saccharomyces cerevisiae

M Alfatah, JH Wong, VG Krishnan, YC Lee, QF Sin… - BMC biology, 2021 - Springer
Background Target of Rapamycin Complex 1 (TORC1) is a highly conserved eukaryotic
protein complex that couples the presence of growth factors and nutrients in the environment …

[PDF][PDF] Metabolism of glucose activates TORC1 through multiple mechanisms in Saccharomyces cerevisiae

…, CJH Goh, TYN Cheng, Y Zhang, A Naaz, JH Wong… - Cell Reports, 2023 - cell.com
Target of Rapamycin Complex 1 (TORC1) is a conserved eukaryotic protein complex that links
the presence of nutrients with cell growth. In Saccharomyces cerevisiae, TORC1 activity is …

Identification of pathways modulating vemurafenib resistance in melanoma cells via a genome-wide CRISPR/Cas9 screen

CJH Goh, JH Wong, C El Farran, BX Tan, CR Coffill… - G3, 2021 - academic.oup.com
Vemurafenib is a BRAF kinase inhibitor (BRAFi) that is used to treat melanoma patients
harboring the constitutively active BRAF-V600E mutation. However, after a few months of …

[HTML][HTML] Diethyl phthalate (DEP) perturbs nitrogen metabolism in Saccharomyces cerevisiae

CJH Goh, L Cui, JH Wong, J Lewis, M Goh… - Scientific Reports, 2022 - nature.com
Phthalates are ubiquitously used as plasticizers in various consumer care products. Diethyl
phthalate (DEP), one of the main phthalates, elicits developmental and reproductive …

[HTML][HTML] Genome-wide analysis of mRNAs associated with mouse peroxisomes

…, M Kremenskoy, AO Batagov, A Preuss, JH Wong… - BMC genomics, 2016 - Springer
Background RNA is often targeted to be localized to the specific subcellular compartments.
Specific localization of mRNA is believed to be an important mechanism for targeting their …

[HTML][HTML] Chemogenomic profiling in yeast reveals antifungal mode-of-action of polyene macrolactam auroramycin

JH Wong, M Alfatah, KW Kong, S Hoon, WL Yeo… - PloS one, 2019 - journals.plos.org
In this study, we report antifungal activity of auroramycin against Candida albicans, Candida
tropicalis, and Cryptococcus neoformans. Auroramycin, a potent antimicrobial doubly …

Chemical-genetic interaction landscape of mono-(2-ethylhexyl)-phthalate using chemogenomic profiling in yeast

M Alfatah, JH Wong, KW Kong, F Utama, S Hoon… - Chemosphere, 2019 - Elsevier
Integration of chemical-genetic interaction data with biological functions provides a mechanistic
understanding of how toxic compounds affect cells. Mono-(2-ethylhexyl)-phthalate (…

[HTML][HTML] Hypoculoside, a sphingoid base-like compound from Acremonium disrupts the membrane integrity of yeast cells

M Alfatah, JH Wong, CE Nge, KW Kong, KN Low… - Scientific Reports, 2019 - nature.com
We have isolated Hypoculoside, a new glycosidic amino alcohol lipid from the fungus
Acremonium sp. F2434 belonging to the order Hypocreales and determined its structure by 2D-…