Design, synthesis and biological evaluation of a series of pyrano chalcone derivatives containing indole moiety as novel anti-tubulin agents

…, F Wang, Y Pu, Z Yang, D Cao, L Ma, J Chen… - Bioorganic & medicinal …, 2014 - Elsevier
A new series of pyrano chalcone derivatives containing indole moiety (3–42, 49a–49r) were
synthesized and evaluated for their antiproliferative activities. Among all the compounds, …

Synthesis and biological evaluation of novel 5-benzylidenethiazolidine-2, 4-dione derivatives for the treatment of inflammatory diseases

…, H Zheng, Z Chen, Q Xu, T Chen, J Chen… - Journal of medicinal …, 2011 - ACS Publications
Twenty-two compounds based on thiazolidine-2,4-dione moiety were synthesized and
evaluated for the inhibitory potency on the production of nitric oxide (NO), inducible nitric oxide …

Gene therapy for visual loss: Opportunities and concerns

JH Lee, JH Wang, J Chen, F Li, TL Edwards… - Progress in retinal and …, 2019 - Elsevier
Many clinical trials using gene therapy have shown significant therapeutic benefits and
exceptional safety records. Increasing evidence is verifying the long sought-after promise that …

CuO-Promoted Construction of N-2-Aryl-Substituted-1,2,3-Triazoles via Azide-Chalcone Oxidative Cycloaddition and Post-Triazole Arylation

…, X Li, J Li, J Chen, X Meng, M Zhao, B Chen - Organic letters, 2012 - ACS Publications
An efficient one-pot three-component stepwise approach for the synthesis of N-2-aryl-substituted-1,2,3-triazoles
has been developed. By using this azide-chalcone oxidative …

Synthesis and biological activity of novel barbituric and thiobarbituric acid derivatives against non-alcoholic fatty liver disease

…, J Chen, L Lin, X Ye, Z Chen, Q Xu, T Chen… - European journal of …, 2011 - Elsevier
Forty-four barbituric acid or thiobarbituric acid derivatives were synthesized and evaluated
for their effects on adipogenesis of 3T3-L1 adipocytes by measuring the expression of …

[HTML][HTML] A novel method of neural differentiation of PC12 cells by using Opti-MEM as a basic induction medium

R Hu, Q Cao, Z Sun, J Chen… - … journal of molecular …, 2018 - spandidos-publications.com
The PC12 cell line is a classical neuronal cell model due to its ability to acquire the sympathetic
neurons features when deal with nerve growth factor (NGF). In the present study, the …

[PDF][PDF] An empirical study of the behavior of active learning for word sense disambiguation

J Chen, A Schein, L Ungar… - Proceedings of the human …, 2006 - aclanthology.org
This paper shows that two uncertaintybased active learning methods, combined with a
maximum entropy model, work well on learning English verb senses. Data analysis on the …

[HTML][HTML] A natural language processing system that links medical terms in electronic health record notes to lay definitions: system development using physician …

J Chen, E Druhl, B Polepalli Ramesh… - Journal of medical …, 2018 - jmir.org
Background Many health care systems now allow patients to access their electronic health
record (EHR) notes online through patient portals. Medical jargon in EHR notes can confuse …

[HTML][HTML] Pan-cancer transcriptome analysis reveals a gene expression signature for the identification of tumor tissue origin

Q Xu, J Chen, S Ni, C Tan, M Xu, L Dong, L Yuan… - Modern Pathology, 2016 - Elsevier
Carcinoma of unknown primary, wherein metastatic disease is present without an identifiable
primary site, accounts for ~3–5% of all cancer diagnoses. Despite the development of …

Learning for biomedical information extraction: Methodological review of recent advances

F Liu, J Chen, A Jagannatha, H Yu - arXiv preprint arXiv:1606.07993, 2016 - arxiv.org
Biomedical information extraction (BioIE) is important to many applications, including clinical
decision support, integrative biology, and pharmacovigilance, and therefore it has been an …