Dear Editor, Since the beginning of this century, humanity has been struck three times by the
coronavirus outbreak. The most recent one is caused by the SARS-CoV-2 virus, which was …

Lipid nanoparticle (LNP) is commonly used to deliver mRNA vaccines. Currently, LNP
optimization primarily relies on screening ionizable lipids by traditional experiments which …

Autoproteolysis has been discovered to play key roles in various biological processes, but
functional autoproteolysis has been rarely reported for transmembrane signaling in …

The universally conserved GTPase elongation factor G (EF-G) catalyzes the translocation of
tRNA and mRNA on the ribosome after peptide bond formation. Despite numerous studies …

Genetic information is translated into proteins by the ribosome. Structural studies of the
ribosome and of its complexes with factors and inhibitors have provided invaluable information …

Prokaryotic CRISPR–Cas immune systems are classified into six types based on their effector
complexes which cleave dsDNA specifically (types I, II and V), ssRNA exclusively (type VI) …

We have developed pLink, software for data analysis of cross-linked proteins coupled with
mass-spectrometry analysis. pLink reliably estimates false discovery rate in cross-link …

Herd immunity achieved through mass vaccination is an effective approach to prevent
contagious diseases. Nonetheless, emerging SARS-CoV-2 variants with frequent mutations …

In addition to storage of genetic information, DNA can also catalyze various reactions. RNA-cleaving
DNAzymes are the catalytic DNAs discovered the earliest, and they can cleave …

Box C/D RNA protein complexes (RNPs) direct site-specific 2′-O-methylation of RNA and
ribosome assembly 1 , 2 , 3 , 4 . The guide RNA in C/D RNP forms base pairs with …