Streptozotocin-induced type 1 diabetes in rodents as a model for studying mitochondrial mechanisms of diabetic β cell glucotoxicity
J Wu, LJ Yan - Diabetes, metabolic syndrome and obesity: targets …, 2015 - Taylor & Francis
Chronic hyperglycemia and the corresponding glucotoxicity are the main pathogenic
mechanisms of diabetes and its complications. Streptozotocin (STZ)-induced diabetic animal …
mechanisms of diabetes and its complications. Streptozotocin (STZ)-induced diabetic animal …
Sources and implications of NADH/NAD+ redox imbalance in diabetes and its complications
NAD + is a fundamental molecule in metabolism and redox signaling. In diabetes and its
complications, the balance between NADH and NAD + can be severely perturbed. On one hand…
complications, the balance between NADH and NAD + can be severely perturbed. On one hand…
[HTML][HTML] Hyperglycemic stress and carbon stress in diabetic glucotoxicity
X Luo, J Wu, S Jing, LJ Yan - Aging and disease, 2016 - ncbi.nlm.nih.gov
Diabetes and its complications are caused by chronic glucotoxicity driven by persistent
hyperglycemia. In this article, we review the mechanisms of diabetic glucotoxicity by focusing …
hyperglycemia. In this article, we review the mechanisms of diabetic glucotoxicity by focusing …
Antimicrobial drug discovery through bacteriophage genomics
…, J McCarty, R Srikumar, D Williams, JJ Wu… - Nature …, 2004 - nature.com
Over evolutionary time bacteriophages have developed unique proteins that arrest critical
cellular processes to commit bacterial host metabolism to phage reproduction. Here, we apply …
cellular processes to commit bacterial host metabolism to phage reproduction. Here, we apply …
[HTML][HTML] Nanoparticles targeted with NGR motif deliver c-myc siRNA and doxorubicin for anticancer therapy
We have designed a PEGylated LPD (liposome-polycation-DNA) nanoparticle for systemic,
specific, and efficient delivery of small interfering RNA (siRNA) into solid tumors in mice by …
specific, and efficient delivery of small interfering RNA (siRNA) into solid tumors in mice by …
[HTML][HTML] First clinical study using HCV protease inhibitor danoprevir to treat COVID-19 patients
…, L Wang, Z Huang, F Gong, X Li, Y Chen, JJ Wu - Medicine, 2020 - journals.lww.com
Methods: This is an open-label, single arm study evaluating the effects of danoprevir
boosted by ritonavir on treatment naïve and experienced COVID-19 patients for the first time. …
boosted by ritonavir on treatment naïve and experienced COVID-19 patients for the first time. …
[HTML][HTML] Potential biochemical mechanisms of lung injury in diabetes
Accumulating evidence has shown that the lung is one of the target organs for microangiopathy
in patients with either type 1 or type 2 diabetes mellitus (DM). Diabetes is associated with …
in patients with either type 1 or type 2 diabetes mellitus (DM). Diabetes is associated with …
Enhanced antitumor efficacy of clinical-grade vasculature-targeted liposomal doxorubicin
Purpose: In vivo evaluation of good manufacturing practice-grade targeted liposomal doxorubicin
(TVT-DOX), bound to a CD13 isoform expressed on the vasculature of solid tumors, in …
(TVT-DOX), bound to a CD13 isoform expressed on the vasculature of solid tumors, in …
Protein modifications as manifestations of hyperglycemic glucotoxicity in diabetes and its complications
Diabetes and its complications are hyperglycemic toxicity diseases. Many metabolic
pathways in this array of diseases become aberrant, which is accompanied with a variety of …
pathways in this array of diseases become aberrant, which is accompanied with a variety of …
[HTML][HTML] Redox imbalance and mitochondrial abnormalities in the diabetic lung
Although the lung is one of the least studied organs in diabetes, increasing evidence
indicates that it is an inevitable target of diabetic complications. Nevertheless, the underlying …
indicates that it is an inevitable target of diabetic complications. Nevertheless, the underlying …