Protein lysine acetylation has emerged as a key posttranslational modification in cellular
regulation, in particular through the modification of histones and nuclear transcription regulators…

Background Hepatocellular carcinoma is a common and aggressive cancer that occurs mainly
in men. We examined microRNA expression patterns, survival, and response to interferon …

Introduction: There are dozens of drugs in development for AD with billions of dollars invested.
Despite the massive investment in AD drugs and a burgeoning pipeline, there have been …

Background The APOE ε4 allele is associated with the risk of late-onset Alzheimer's disease.
The age at which memory decline diverges among persons who are homozygous for the …

The B rain and B ody D onation P rogram ( BBDP ) at B anner S un H ealth R esearch I
nstitute ( http://www.brainandbodydonationprogram.org ) started in 1987 with brain‐only …

Mature HIV-1 particles contain conical-shaped capsids that enclose the viral RNA genome
and perform essential functions in the virus life cycle. Previous structural analysis of two- and …

Importance In vivo imaging of brain β-amyloid, a hallmark of Alzheimer disease, may assist
in the clinical assessment of suspected Alzheimer disease. Objective To determine the …

Human immunodeficiency virus type 1 (HIV-1) infection is dependent on the proper disassembly
of the viral capsid, or “uncoating,” in target cells. The HIV-1 capsid consists of a conical …

Retrovirus particles are not infectious until they undergo proteolytic maturation to form a
functional core. Here we report a link between human immunodeficiency virus type 1 (HIV-1) …

Background and Purpose—17β-Estradiol (E2) has been reported to exert neuroprotective
effects when administered before an ischemic insult. This study was designed to determine …