User profiles for Jiorgos Kourelis

Jiorgos Kourelis

Postdoctoral Scientist, The Sainsbury Laboratory, Norwich
Verified email at TSL.ac.uk
Cited by 1677

Defended to the nines: 25 years of resistance gene cloning identifies nine mechanisms for R protein function

J Kourelis, RAL Van Der Hoorn - The Plant Cell, 2018 - academic.oup.com
Plants have many, highly variable resistance (R) gene loci, which provide resistance to a
variety of pathogens. The first R gene to be cloned, maize (Zea mays) Hm1, was published …

Emerging principles in the design of bioengineered made-to-order plant immune receptors

C Marchal, H Pai, S Kamoun, J Kourelis - Current Opinion in Plant Biology, 2022 - Elsevier
Crop yield and global food security are under constant threat from plant pathogens with the
potential to cause epidemics. Traditional breeding for disease resistance can be too slow to …

Activation and regulation of NLR immune receptor networks

J Kourelis, H Adachi - Plant and Cell Physiology, 2022 - academic.oup.com
Plants have many types of immune receptors that recognize diverse pathogen molecules and
activate the innate immune system. The intracellular immune receptor family of nucleotide-…

Effector‐dependent activation and oligomerization of plant NRC class helper NLRs by sensor NLR immune receptors Rpi‐amr3 and Rpi‐amr1

…, L Derevnina, MP Contreras, J Kourelis… - The EMBO …, 2023 - embopress.org
Plant pathogens compromise crop yields. Plants have evolved robust innate immunity that
depends in part on intracellular Nucleotide‐binding, Leucine rich‐Repeat (NLR) immune …

Sensor NLR immune proteins activate oligomerization of their NRC helpers in response to plant pathogens

…, C Duggan, ELH Yuen, AV Cruces, J Kourelis… - The EMBO …, 2023 - embopress.org
Nucleotide‐binding domain leucine‐rich repeat (NLR) immune receptors are important
components of plant and metazoan innate immunity that can function as individual units or as …

NLR immune receptor–nanobody fusions confer plant disease resistance

J Kourelis, C Marchal, A Posbeyikian, A Harant… - Science, 2023 - science.org
Plant pathogens cause recurrent epidemics, threatening crop yield and global food security.
Efforts to retool the plant immune system have been limited to modifying natural …

[HTML][HTML] RefPlantNLR is a comprehensive collection of experimentally validated plant disease resistance proteins from the NLR family

J Kourelis, T Sakai, H Adachi, S Kamoun - PLoS Biology, 2021 - journals.plos.org
Reference datasets are critical in computational biology. They help define canonical biological
features and are essential for benchmarking studies. Here, we describe a comprehensive …

Glycosidase and glycan polymorphism control hydrolytic release of immunogenic flagellin peptides

…, B Chandrasekar, N Sanguankiattichai, J Kourelis… - Science, 2019 - science.org
INTRODUCTION Immunogenic flagellin fragments are a signature of bacterial invasion in both
plants and animals. Plants recognize flagellin fragments via flagellin sensitive 2 (FLS2), a …

[HTML][HTML] Mitochondrial uncouplers inhibit clathrin-mediated endocytosis largely through cytoplasmic acidification

…, S Scholl, X Zarza, M Heilmann, J Kourelis… - Nature …, 2016 - nature.com
ATP production requires the establishment of an electrochemical proton gradient across the
inner mitochondrial membrane. Mitochondrial uncouplers dissipate this proton gradient and …

[HTML][HTML] The helper NLR immune protein NRC3 mediates the hypersensitive cell death caused by the cell-surface receptor Cf-4

J Kourelis, MP Contreras, A Harant, H Pai… - PLoS …, 2022 - journals.plos.org
Cell surface pattern recognition receptors (PRRs) activate immune responses that can
include the hypersensitive cell death. However, the pathways that link PRRs to the cell death …