User profiles for Jiorgos Kourelis
Jiorgos KourelisPostdoctoral Scientist, The Sainsbury Laboratory, Norwich Verified email at TSL.ac.uk Cited by 1677 |
Defended to the nines: 25 years of resistance gene cloning identifies nine mechanisms for R protein function
J Kourelis, RAL Van Der Hoorn - The Plant Cell, 2018 - academic.oup.com
Plants have many, highly variable resistance (R) gene loci, which provide resistance to a
variety of pathogens. The first R gene to be cloned, maize (Zea mays) Hm1, was published …
variety of pathogens. The first R gene to be cloned, maize (Zea mays) Hm1, was published …
Emerging principles in the design of bioengineered made-to-order plant immune receptors
Crop yield and global food security are under constant threat from plant pathogens with the
potential to cause epidemics. Traditional breeding for disease resistance can be too slow to …
potential to cause epidemics. Traditional breeding for disease resistance can be too slow to …
Activation and regulation of NLR immune receptor networks
J Kourelis, H Adachi - Plant and Cell Physiology, 2022 - academic.oup.com
Plants have many types of immune receptors that recognize diverse pathogen molecules and
activate the innate immune system. The intracellular immune receptor family of nucleotide-…
activate the innate immune system. The intracellular immune receptor family of nucleotide-…
Effector‐dependent activation and oligomerization of plant NRC class helper NLRs by sensor NLR immune receptors Rpi‐amr3 and Rpi‐amr1
Plant pathogens compromise crop yields. Plants have evolved robust innate immunity that
depends in part on intracellular Nucleotide‐binding, Leucine rich‐Repeat (NLR) immune …
depends in part on intracellular Nucleotide‐binding, Leucine rich‐Repeat (NLR) immune …
Sensor NLR immune proteins activate oligomerization of their NRC helpers in response to plant pathogens
Nucleotide‐binding domain leucine‐rich repeat (NLR) immune receptors are important
components of plant and metazoan innate immunity that can function as individual units or as …
components of plant and metazoan innate immunity that can function as individual units or as …
NLR immune receptor–nanobody fusions confer plant disease resistance
Plant pathogens cause recurrent epidemics, threatening crop yield and global food security.
Efforts to retool the plant immune system have been limited to modifying natural …
Efforts to retool the plant immune system have been limited to modifying natural …
[HTML][HTML] RefPlantNLR is a comprehensive collection of experimentally validated plant disease resistance proteins from the NLR family
Reference datasets are critical in computational biology. They help define canonical biological
features and are essential for benchmarking studies. Here, we describe a comprehensive …
features and are essential for benchmarking studies. Here, we describe a comprehensive …
Glycosidase and glycan polymorphism control hydrolytic release of immunogenic flagellin peptides
INTRODUCTION Immunogenic flagellin fragments are a signature of bacterial invasion in both
plants and animals. Plants recognize flagellin fragments via flagellin sensitive 2 (FLS2), a …
plants and animals. Plants recognize flagellin fragments via flagellin sensitive 2 (FLS2), a …
[HTML][HTML] Mitochondrial uncouplers inhibit clathrin-mediated endocytosis largely through cytoplasmic acidification
…, S Scholl, X Zarza, M Heilmann, J Kourelis… - Nature …, 2016 - nature.com
ATP production requires the establishment of an electrochemical proton gradient across the
inner mitochondrial membrane. Mitochondrial uncouplers dissipate this proton gradient and …
inner mitochondrial membrane. Mitochondrial uncouplers dissipate this proton gradient and …
[HTML][HTML] The helper NLR immune protein NRC3 mediates the hypersensitive cell death caused by the cell-surface receptor Cf-4
J Kourelis, MP Contreras, A Harant, H Pai… - PLoS …, 2022 - journals.plos.org
Cell surface pattern recognition receptors (PRRs) activate immune responses that can
include the hypersensitive cell death. However, the pathways that link PRRs to the cell death …
include the hypersensitive cell death. However, the pathways that link PRRs to the cell death …