The coronavirus disease (COVID-19) caused by SARS-CoV-2 is creating tremendous health
problems and economical challenges for mankind. To date, no effective drug is available to …

The coronavirus disease (COVID-19) caused by SARS-CoV-2 is creating tremendous health
problems and economical challenges for mankind. To date, no effective drug is available to …

Here we present the crystal structure of SARS-CoV-2 main protease (M pro ) covalently
bound to 2-methyl-1-tetralone. This complex was obtained by co-crystallization of M pro with …

Here we present the crystal structure of SARS-CoV-2 main protease (Mpro) covalently bound
to 2-methyl-1-tetralone. This complex was obtained by co-crystallization of Mpro with HEAT …

Careful selection of photocaging approaches is critical to achieve fast and well synchronized
reaction initiation and perform successful time-resolved structural biology experiments. This …

… Each data set has an associated model with J C α atoms with 3D coordinate vectors c j,n
in real space. J n atoms in data set n have been modelled for every C α atom j, and J − J n …

Here, we illustrate what happens inside the catalytic cleft of an enzyme when substrate or
ligand binds on single-millisecond timescales. The initial phase of the enzymatic cycle is …

Compound repurposing is an important strategy for the identification of effective treatment
options against SARS-CoV-2 infection and COVID-19 disease. In this regard, SARS-CoV-2 …

In this study, we follow the diffusion and buildup of occupancy of the substrate ceftriaxone in
M. tuberculosis β-lactamase BlaC microcrystals by structural analysis of the enzyme …

85 The coronavirus disease (COVID-19) caused by SARS-CoV-2 is creating 86 tremendous
health problems and economical challenges for mankind. To date, no 87 effective drug is …