Protein interactions form a network whose structure drives cellular function and whose
organization informs biological inquiry. Using high-throughput affinity-purification mass …

Immune evasion is a major obstacle for cancer treatment. Common mechanisms of evasion
include impaired antigen presentation caused by mutations or loss of heterozygosity of the …

Isobaric labeling empowers proteome-wide expression measurements simultaneously
across multiple samples. Here an expanded set of 16 isobaric reagents based on an isobutyl-…

Mass spectrometry (MS) coupled toisobaric labeling has developed rapidly into a powerful
strategy for high-throughput protein quantification. Sample multiplexing and exceptional …

Metformin has utility in cancer prevention and treatment, though the mechanisms for these
effects remain elusive. Through genetic screening in C. elegans, we uncover two metformin …

Isobaric labeling is a powerful strategy for quantitative mass spectrometry-based proteomic
investigations. A complication of such analyses has been the co-isolation of multiple analytes …

Multiplexed, isobaric tagging methods are powerful techniques to increase throughput,
precision, and accuracy in quantitative proteomics. The dynamic range and accuracy of …

Effective wildfire management begins with fire prevention and the assessment of the local fire
danger. Typical approaches to fire danger classification rely heavily on manual analysis for …

The physiology of a cell can be viewed as the product of thousands of proteins acting in
concert to shape the cellular response. Coordination is achieved in part through networks of …

Damaged mitochondria are detrimental to cellular homeostasis. One mechanism for
removal of damaged mitochondria involves the PINK1-PARKIN pathway, which poly-ubiquitylates …