To induce adaptive immunity, dendritic cells (DCs) migrate through afferent lymphatic vessels
(LVs) to draining lymph nodes (dLNs). This process occurs in several consecutive steps. …

With conformation-specific nanobodies being used for a wide range of structural, biochemical,
and cell biological applications, there is a demand for antigen-binding fragments (Fabs) …

C-linked glycosylation is essential for the trafficking, folding and function of secretory and
transmembrane proteins involved in cellular communication processes. The tryptophan C-…

In eukaryotic protein N-glycosylation, a series of glycosyltransferases catalyse the biosynthesis
of a dolichylpyrophosphate-linked oligosaccharide before its transfer onto acceptor …

Cellular uptake of vitamin B12 (cobalamin) requires capture of transcobalamin (TC) from the
plasma by CD320, a ubiquitous cell surface receptor of the LDLR family. Here we present …

Oligosaccharyltransferase (OST) is the central enzyme of N-linked protein glycosylation. It
catalyzes the transfer of a pre-assembled glycan, GlcNAc 2 Man 9 Glc 3 , from a dolichyl-…

Important reactions in biology and biocatalysis involve proton abstraction from carbon.
When the resulting anionic charge is delocalized from carbon to an oxygen atom, these …

Vitamin B12 (cyanocobalamin, CNCbl) is an essential cofactor-precursor for two biochemical
reactions in humans. When ingested, cobalamins (Cbl) are transported via a multistep …

Cellular uptake of vitamin B 12 in humans is mediated by the endocytosis of the B 12 carrier
protein transcobalamin (TC) via its cognate cell surface receptor TCblR (or CD320), …

Structural biology allows us to shed light onto the smallest processes of life. The genetic
information that is stored in the DNA of every living cell holds the building plans for proteins: …