User profiles for Joëlle Bigay
BIGAY JoelleIPMC/CNRS (UMR7275) UCA 660 Route des Lucioles SOPHIA ANTIPOLIS 06560 … Verified email at ipmc.cnrs.fr Cited by 5677 |
[HTML][HTML] A four-step cycle driven by PI (4) P hydrolysis directs sterol/PI (4) P exchange by the ER-Golgi tether OSBP
Several proteins at endoplasmic reticulum (ER)-Golgi membrane contact sites contain a PH
domain that interacts with the Golgi phosphoinositide PI(4)P, a FFAT motif that interacts with …
domain that interacts with the Golgi phosphoinositide PI(4)P, a FFAT motif that interacts with …
[PDF][PDF] Curvature, lipid packing, and electrostatics of membrane organelles: defining cellular territories in determining specificity
Whereas some rare lipids contribute to the identity of cell organelles, we focus on the abundant
lipids that form the matrix of organelle membranes. Observations using bioprobes and …
lipids that form the matrix of organelle membranes. Observations using bioprobes and …
ArfGAP1 responds to membrane curvature through the folding of a lipid packing sensor motif
ArfGAP1 promotes GTP hydrolysis in Arf1, a small G protein that interacts with lipid membranes
and drives the assembly of the COPI coat in a GTP‐dependent manner. The activity of …
and drives the assembly of the COPI coat in a GTP‐dependent manner. The activity of …
α-Synuclein and ALPS motifs are membrane curvature sensors whose contrasting chemistry mediates selective vesicle binding
IM Pranke, V Morello, J Bigay, K Gibson… - Journal of Cell …, 2011 - rupress.org
Membrane curvature sensors have diverse structures and chemistries, suggesting that they
might have the intrinsic capacity to discriminate between different types of vesicles in cells. In …
might have the intrinsic capacity to discriminate between different types of vesicles in cells. In …
Sterol transfer, PI 4P consumption, and control of membrane lipid order by endogenous OSBP
The network of proteins that orchestrate the distribution of cholesterol among cellular organelles
is not fully characterized. We previously proposed that oxysterol‐binding protein ( OSBP …
is not fully characterized. We previously proposed that oxysterol‐binding protein ( OSBP …
The oxysterol-binding protein cycle: burning off PI (4) P to transport cholesterol
To maintain an asymmetric distribution of ions across membranes, protein pumps displace
ions against their concentration gradient by using chemical energy. Here, we describe a …
ions against their concentration gradient by using chemical energy. Here, we describe a …
Lipid packing sensed by ArfGAP1 couples COPI coat disassembly to membrane bilayer curvature
Protein coats deform flat lipid membranes into buds and capture membrane proteins to form
transport vesicles 1 , 2 , 3 . The assembly/disassembly cycle of the COPI coat on Golgi …
transport vesicles 1 , 2 , 3 . The assembly/disassembly cycle of the COPI coat on Golgi …
Two lipid-packing sensor motifs contribute to the sensitivity of ArfGAP1 to membrane curvature
…, G Drin, S Levi, M Rawet, D Cassel, J Bigay… - Biochemistry, 2007 - ACS Publications
ArfGAP1 (Arf GTPase activating protein 1) controls the cycling of the COPI coat on Golgi
membranes by catalyzing GTP hydrolysis in the small G protein Arf1. ArfGAP1 contains a central …
membranes by catalyzing GTP hydrolysis in the small G protein Arf1. ArfGAP1 contains a central …
[HTML][HTML] Role of protein-phospholipid interactions in the activation of ARF1 by the guanine nucleotide exchange factor Arno
S Paris, S Béraud-Dufour, S Robineau, J Bigay… - Journal of Biological …, 1997 - ASBMB
Arno is a 47-kDa human protein recently identified as a guanine nucleotide exchange factor
for ADP ribosylation factor 1 (ARF1) with a central Sec7 domain responsible for the …
for ADP ribosylation factor 1 (ARF1) with a central Sec7 domain responsible for the …
[PDF][PDF] Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein
JRPM Strating, L van der Linden, L Albulescu, J Bigay… - Cell reports, 2015 - cell.com
Itraconazole (ITZ) is a well-known antifungal agent that also has anticancer activity. In this
study, we identify ITZ as a broad-spectrum inhibitor of enteroviruses (eg, poliovirus, …
study, we identify ITZ as a broad-spectrum inhibitor of enteroviruses (eg, poliovirus, …