User profiles for Joëlle Bigay

BIGAY Joelle

IPMC/CNRS (UMR7275) UCA 660 Route des Lucioles SOPHIA ANTIPOLIS 06560 …
Verified email at ipmc.cnrs.fr
Cited by 5677

[HTML][HTML] A four-step cycle driven by PI (4) P hydrolysis directs sterol/PI (4) P exchange by the ER-Golgi tether OSBP

B Mesmin, J Bigay, JM Von Filseck, S Lacas-Gervais… - Cell, 2013 - cell.com
Several proteins at endoplasmic reticulum (ER)-Golgi membrane contact sites contain a PH
domain that interacts with the Golgi phosphoinositide PI(4)P, a FFAT motif that interacts with …

[PDF][PDF] Curvature, lipid packing, and electrostatics of membrane organelles: defining cellular territories in determining specificity

J Bigay, B Antonny - Developmental cell, 2012 - cell.com
Whereas some rare lipids contribute to the identity of cell organelles, we focus on the abundant
lipids that form the matrix of organelle membranes. Observations using bioprobes and …

ArfGAP1 responds to membrane curvature through the folding of a lipid packing sensor motif

J Bigay, JF Casella, G Drin, B Mesmin… - The EMBO journal, 2005 - embopress.org
ArfGAP1 promotes GTP hydrolysis in Arf1, a small G protein that interacts with lipid membranes
and drives the assembly of the COPI coat in a GTP‐dependent manner. The activity of …

α-Synuclein and ALPS motifs are membrane curvature sensors whose contrasting chemistry mediates selective vesicle binding

IM Pranke, V Morello, J Bigay, K Gibson… - Journal of Cell …, 2011 - rupress.org
Membrane curvature sensors have diverse structures and chemistries, suggesting that they
might have the intrinsic capacity to discriminate between different types of vesicles in cells. In …

Sterol transfer, PI 4P consumption, and control of membrane lipid order by endogenous OSBP

B Mesmin, J Bigay, J Polidori, D Jamecna… - The EMBO …, 2017 - embopress.org
The network of proteins that orchestrate the distribution of cholesterol among cellular organelles
is not fully characterized. We previously proposed that oxysterol‐binding protein ( OSBP …

The oxysterol-binding protein cycle: burning off PI (4) P to transport cholesterol

B Antonny, J Bigay, B Mesmin - Annual review of biochemistry, 2018 - annualreviews.org
To maintain an asymmetric distribution of ions across membranes, protein pumps displace
ions against their concentration gradient by using chemical energy. Here, we describe a …

Lipid packing sensed by ArfGAP1 couples COPI coat disassembly to membrane bilayer curvature

J Bigay, P Gounon, S Robineau, B Antonny - Nature, 2003 - nature.com
Protein coats deform flat lipid membranes into buds and capture membrane proteins to form
transport vesicles 1 , 2 , 3 . The assembly/disassembly cycle of the COPI coat on Golgi …

Two lipid-packing sensor motifs contribute to the sensitivity of ArfGAP1 to membrane curvature

…, G Drin, S Levi, M Rawet, D Cassel, J Bigay… - Biochemistry, 2007 - ACS Publications
ArfGAP1 (Arf GTPase activating protein 1) controls the cycling of the COPI coat on Golgi
membranes by catalyzing GTP hydrolysis in the small G protein Arf1. ArfGAP1 contains a central …

[HTML][HTML] Role of protein-phospholipid interactions in the activation of ARF1 by the guanine nucleotide exchange factor Arno

S Paris, S Béraud-Dufour, S Robineau, J Bigay… - Journal of Biological …, 1997 - ASBMB
Arno is a 47-kDa human protein recently identified as a guanine nucleotide exchange factor
for ADP ribosylation factor 1 (ARF1) with a central Sec7 domain responsible for the …

[PDF][PDF] Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein

JRPM Strating, L van der Linden, L Albulescu, J Bigay… - Cell reports, 2015 - cell.com
Itraconazole (ITZ) is a well-known antifungal agent that also has anticancer activity. In this
study, we identify ITZ as a broad-spectrum inhibitor of enteroviruses (eg, poliovirus, …