Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

…, T Saito, S Narushima, K Hase, S Kim, JV Fritz… - Nature, 2013 - nature.com
Manipulation of the gut microbiota holds great promise for the treatment of inflammatory and
allergic diseases 1 , 2 . Although numerous probiotic microorganisms have been identified 3 …

[HTML][HTML] A microfluidics-based in vitro model of the gastrointestinal human–microbe interface

P Shah, JV Fritz, E Glaab, MS Desai… - Nature …, 2016 - nature.com
Abstract Changes in the human gastrointestinal microbiome are associated with several
diseases. To infer causality, experiments in representative models are essential, but widely …

[HTML][HTML] Birth mode is associated with earliest strain-conferred gut microbiome functions and immunostimulatory potential

L Wampach, A Heintz-Buschart, JV Fritz… - Nature …, 2018 - nature.com
The rate of caesarean section delivery (CSD) is increasing worldwide. It remains unclear
whether disruption of mother-to-neonate transmission of microbiota through CSD occurs and …

[HTML][HTML] From meta-omics to causality: experimental models for human microbiome research

JV Fritz, MS Desai, P Shah, JG Schneider, P Wilmes - Microbiome, 2013 - Springer
Large-scale ‘meta-omic’ projects are greatly advancing our knowledge of the human
microbiome and its specific role in governing health and disease states. A myriad of ongoing …

The extracellular RNA complement of Escherichia coli

A Ghosal, BB Upadhyaya, JV Fritz… - …, 2015 - Wiley Online Library
The secretion of biomolecules into the extracellular milieu is a common and well‐conserved
phenomenon in biology. In bacteria, secreted biomolecules are not only involved in intra‐…

Sources and functions of extracellular small RNAs in human circulation

JV Fritz, A Heintz-Buschart, A Ghosal… - Annual review of …, 2016 - annualreviews.org
Various biotypes of endogenous small RNAs (sRNAs) have been detected in human
circulation, including microRNAs, transfer RNAs, ribosomal RNA, and yRNA fragments. These …

Prevalence of SARS-CoV-2 infection in the Luxembourgish population–the CON-VINCE study

…, JD Turner, K Beaumont, CPC Gomes, JV Fritz… - MedRxiv, 2020 - medrxiv.org
BACKGROUND The World Health Organization declared the outbreak of coronavirus disease
to be a public health emergency of international concern on January 30, 2020. The first …

[HTML][HTML] Gene Regulatory Network Inference of Immunoresponsive Gene 1 (IRG1) Identifies Interferon Regulatory Factor 1 (IRF1) as Its Transcriptional Regulator in …

A Tallam, TM Perumal, PM Antony, C Jäger, JV Fritz… - PLoS …, 2016 - journals.plos.org
Immunoresponsive gene 1 (IRG1) is one of the highest induced genes in macrophages under
pro-inflammatory conditions. Its function has been recently described: it codes for immune-…

HIV-1 Vpu blocks recycling and biosynthetic transport of the intrinsic immunity factor CD317/tetherin to overcome the virion release restriction

S Schmidt, JV Fritz, J Bitzegeio, OT Fackler, OT Keppler - MBio, 2011 - Am Soc Microbiol
The intrinsic immunity factor CD317 (BST-2/HM1.24/tetherin) imposes a barrier to HIV-1
release at the cell surface that can be overcome by the viral protein Vpu. Expression of Vpu …

[HTML][HTML] Human tetherin exerts strong selection pressure on the HIV-1 group N Vpu protein

…, M Peeters, GH Learn, F Bibollet-Ruche, JV Fritz… - PLoS …, 2012 - journals.plos.org
HIV-1 groups M and N emerged within the last century following two independent cross-species
transmissions of SIVcpz from chimpanzees to humans. In contrast to pandemic group M …