We report here the discovery of a ligand-accelerated1 mode for methyltrioxorhenium (MTO)-catalyzed
olefin epoxidations. 2, 3 Aqueous H2O2 is the oxidant, and the ligands are …

The nonlinear model of a continuous stirred tank reactor is shown to be flat. The flatness
permits the design of suitable trajectories on the basis of the explicit stationary solution and the …

<p>Generalized states, the state representations of which depend on time derivatives of the
input, are naturally used in the control design for flat systems. Quasi-static feedback of these …

Three decades after identification of the Ras oncogene, no effective treatments for Ras mutant
tumors are available despite intensive drug discovery efforts. Here we critically review the …

The Ras gene is frequently mutated in cancer, and mutant Ras drives tumorigenesis. Although
Ras is a central oncogene, small molecules that bind to Ras in a well-defined manner …

There has been a resurgence of interest in the use of phenotypic screens in drug discovery
as an alternative to target-focused approaches. Given that oncology is currently the most …

Ghrelin, through action on its receptor, GH secretagogue receptor type 1a (GHS-R1a),
exerts a variety of metabolic functions including stimulation of appetite and weight gain and …

seco-Cyclothialidines are a promising class of bacterial DNA gyrase B subunit inhibitors. A
new seco-cyclothialidine derivative containing a dioxazine moiety, BAY 50-7952, was …

… Joachim Rudolph … Rudolph, Joachim: Flatness Based Control of Distributed Parameter
Systems / Joachim Rudolph. Aachen : Shaker, 2003 …

Within druggable target space, new small-molecule modalities, particularly covalent inhibitors
and targeted degraders, have expanded the repertoire of medicinal chemists. Molecules …