Autoreactive T cell responses have a crucial role in central nervous system (CNS) diseases
such as multiple sclerosis. Recent data indicate that CNS autoimmunity can be mediated by …

Multiple sclerosis is an inflammatory, demyelinating disease of the central nervous system (CNS)
characterized by a wide range of clinical signs 1 . The location of lesions in the CNS is …

We constructed a transgenic mouse model that mimics the human autoimmune disease
multiple sclerosis in its spontaneous induction and pathology. Transgenic mice were …

This protocol details a method to actively induce experimental allergic encephalomyelitis (EAE),
a widely used animal model for studies of multiple sclerosis. EAE is induced by …

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS)
characterized by plaques of infiltrating CD4 + and CD8 + T cells. Studies of MS and experimental …

Cytokines provide cells with the ability to communicate with one another and orchestrate
complex multicellular behaviour. There is an emerging understanding of the role that cytokines …

Encounters with antigen can stimulate T cells to become activated and proliferate, become
nonresponsive to antigen, or to die. T cell death was shown to be a physiological response to …

Experimental allergic encephalomyelitis (EAE) is a widely used animal model of the human
demyelinating disease multiple sclerosis. EAE is initiated by immunization with myelin …

Oligodendrocyte precursor cells (OPCs) are abundant in the adult central nervous system,
and have the capacity to regenerate oligodendrocytes and myelin. However, in inflammatory …

Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous
system (CNS) manifested with varying clinical course, pathology, and inflammatory patterns. …