Standardization of mesenchymal stromal cells (MSCs) remains a major obstacle in regenerative
medicine. Starting material and culture expansion affect cell preparations and render …

Standardization of mesenchymal stromal cells (MSCs) is hampered by the lack of a precise
definition for these cell preparations; for example, there are no molecular markers to discern …

BACKGROUND White blood cell counts are routinely measured with automated hematology
analyzers, by flow cytometry, or by manual counting. Here, we introduce an alternative …

De novo DNA methyltransferase 3A (DNMT3A) plays pivotal roles in hematopoietic
differentiation. In this study, we followed the hypothesis that alternative splicing of DNMT3A has …

Background Epigenetic aberrations play a central role in the pathophysiology of acute
myeloid leukemia (AML). It has been shown that molecular signatures based on DNA-methylation …

Background DNA methylation is involved in the epigenetic regulation of gene expression
during developmental processes and is primarily established by the DNA methyltransferase 3A …

Background Differentiation of induced pluripotent stem cells (iPSCs) toward hematopoietic
progenitor cells (HPCs) raises high hopes for disease modeling, drug screening, and cellular …

Background Transplantation of human hematopoietic stem cells into immunodeficient mice
provides a powerful in vivo model system to gain functional insights into hematopoietic …

Editorial Wagner, Fernandez-Rebollo & Frobel based on DNAm at six specific CpG sites
can predict passage numbers and cumulative population doublings of MSCs and fibroblasts …

To better standardize MSC preparations, it has been proposed to utilize a well-defined
reference cell material that can be used to track consistency and potency of MSCs [5]. This …