Central memory CD8 + T cells (Tcm) control systemic secondary infections and can protect
from chronic infection and cancer as a result of their stem-cell-like capacity to expand, …

The formation of central CD8 T cell memory in response to infection depends on the
transcription factor Tcf1 (Tcf7). Tcf1 is expressed at high levels in naive CD8 T cells but …

In response to infection, naïve CD8 + T (T N ) cells yield a large pool of short-lived terminal
effector (T TE ) cells that eliminate infected host cells. In parallel, a minor population of stem …

Objective FOXE 1 is a transcription factor required for thyroid differentiation and function.
FOXE1 locus polymorphisms (chromosome 9q22.33) were recently associated with increased …

Increasing the uptake of the 13-valent pneumococcal conjugate vaccine (PCV13) in children
is expected to alter the serotypes causing invasive pneumococcal disease (IPD) in adults …

Thymus autonomy is the capacity of the thymus to maintain T lymphocyte development and
export independently of bone marrow contribution. Prolonging thymus autonomy was shown …

Optimization of protein formulations at subzero temperatures is required for many applications
such as storage, transport, and lyophilization. Using isochoric cooling (constant volume) is …

We previously reported that despite the use of pneumococcal conjugate vaccines (PCVs),
vaccine serotypes remained important causes of pneumonia with pleural effusion and …

Cell competition in the thymus is a homeostatic process that drives turnover. If the process is
impaired, thymopoiesis can be autonomously maintained for several weeks, but this causes …

The introduction of pneumococcal conjugate vaccines PCV7 and PCV13 led to decreases
in incidence of pediatric invasive pneumococcal disease (pIPD) and changes in serotype …