User profiles for Joana M. Gaspar
Joana M. GasparFederal University of Santa Catarina Verified email at ufsc.br Cited by 1095 |
[HTML][HTML] Hippocampal function is impaired by a short-term high-fat diet in mice: Increased blood–brain barrier permeability and neuroinflammation as triggering events
Worldwide, and especially in Western civilizations, most of the staple diets contain high
amounts of fat and refined carbohydrates, leading to an increasing number of obese individuals. …
amounts of fat and refined carbohydrates, leading to an increasing number of obese individuals. …
Inside the diabetic brain: role of different players involved in cognitive decline
Diabetes mellitus is the most common metabolic disease, and its prevalence is increasing.
A growing body of evidence, both in animal models and epidemiological studies, has …
A growing body of evidence, both in animal models and epidemiological studies, has …
Neuroinflammation in autism spectrum disorders: Exercise as a “pharmacological” tool
The worldwide prevalence of ASD is around 1%. Although the pathogenesis of ASD is not
entirely understood, it is recognized that a combination of genetic, epigenetics, environmental …
entirely understood, it is recognized that a combination of genetic, epigenetics, environmental …
[HTML][HTML] Obesity-induced brain neuroinflammatory and mitochondrial changes
LO Schmitt, JM Gaspar - Metabolites, 2023 - mdpi.com
Obesity is defined as abnormal and excessive fat accumulation, and it is a risk factor for
developing metabolic and neurodegenerative diseases and cognitive deficits. Obesity is caused …
developing metabolic and neurodegenerative diseases and cognitive deficits. Obesity is caused …
[HTML][HTML] Hypoxia inducible factor as a central regulator of metabolism–implications for the development of obesity
JM Gaspar, LA Velloso - Frontiers in Neuroscience, 2018 - frontiersin.org
The hypothalamus plays a major role in the regulation of food intake and energy expenditure.
In the last decade, it was demonstrated that consumption of high-fat diets triggers the …
In the last decade, it was demonstrated that consumption of high-fat diets triggers the …
Tauroursodeoxycholic acid protects retinal neural cells from cell death induced by prolonged exposure to elevated glucose
JM Gaspar, A Martins, R Cruz, CMP Rodrigues… - Neuroscience, 2013 - Elsevier
Diabetic retinopathy is one of the most frequent causes of blindness in adults in the Western
countries. Although diabetic retinopathy is considered a vascular disease, several reports …
countries. Although diabetic retinopathy is considered a vascular disease, several reports …
[HTML][HTML] Diabetes changes the levels of ionotropic glutamate receptors in the rat retina
AR Santiago, JM Gaspar, FI Baptista… - Molecular …, 2009 - ncbi.nlm.nih.gov
Purpose Diabetic retinopathy (DR) is a leading cause of vision loss and blindness among
adults between the age 20 to 74. Changes in ionotropic glutamate receptor subunit …
adults between the age 20 to 74. Changes in ionotropic glutamate receptor subunit …
[HTML][HTML] Deep brain stimulation for obesity: a review and future directions
The global prevalence of obesity has been steadily increasing. Although pharmacotherapy
and bariatric surgeries can be useful adjuvants in the treatment of morbid obesity, they may …
and bariatric surgeries can be useful adjuvants in the treatment of morbid obesity, they may …
TGF-β1 down-regulation in the mediobasal hypothalamus attenuates hypothalamic inflammation and protects against diet-induced obesity
Background The consumption of large amounts of dietary fats induces hypothalamic inflammation
and impairs the function of the melanocortin system, leading to a defective regulation …
and impairs the function of the melanocortin system, leading to a defective regulation …
[HTML][HTML] Exercise improves the social and behavioral skills of children and adolescent with autism spectrum disorders
Background Currently, there is no standard treatment for Autism Spectrum Disorders (ASD),
but there are many ways to minimize the symptoms and maximize abilities. Some studies …
but there are many ways to minimize the symptoms and maximize abilities. Some studies …