User profiles for Joana M. Gaspar

Joana M. Gaspar

Federal University of Santa Catarina
Verified email at ufsc.br
Cited by 1095

[HTML][HTML] Hippocampal function is impaired by a short-term high-fat diet in mice: Increased blood–brain barrier permeability and neuroinflammation as triggering events

…, HS Brunetta, DF Engel, JM Gaspar… - Frontiers in …, 2021 - frontiersin.org
Worldwide, and especially in Western civilizations, most of the staple diets contain high
amounts of fat and refined carbohydrates, leading to an increasing number of obese individuals. …

Inside the diabetic brain: role of different players involved in cognitive decline

JM Gaspar, FI Baptista, MP Macedo… - ACS chemical …, 2016 - ACS Publications
Diabetes mellitus is the most common metabolic disease, and its prevalence is increasing.
A growing body of evidence, both in animal models and epidemiological studies, has …

Neuroinflammation in autism spectrum disorders: Exercise as a “pharmacological” tool

…, AB Lima, T Nunes, HM Carvalho, JM Gaspar - Neuroscience & …, 2021 - Elsevier
The worldwide prevalence of ASD is around 1%. Although the pathogenesis of ASD is not
entirely understood, it is recognized that a combination of genetic, epigenetics, environmental …

[HTML][HTML] Obesity-induced brain neuroinflammatory and mitochondrial changes

LO Schmitt, JM Gaspar - Metabolites, 2023 - mdpi.com
Obesity is defined as abnormal and excessive fat accumulation, and it is a risk factor for
developing metabolic and neurodegenerative diseases and cognitive deficits. Obesity is caused …

[HTML][HTML] Hypoxia inducible factor as a central regulator of metabolism–implications for the development of obesity

JM Gaspar, LA Velloso - Frontiers in Neuroscience, 2018 - frontiersin.org
The hypothalamus plays a major role in the regulation of food intake and energy expenditure.
In the last decade, it was demonstrated that consumption of high-fat diets triggers the …

Tauroursodeoxycholic acid protects retinal neural cells from cell death induced by prolonged exposure to elevated glucose

JM Gaspar, A Martins, R Cruz, CMP Rodrigues… - Neuroscience, 2013 - Elsevier
Diabetic retinopathy is one of the most frequent causes of blindness in adults in the Western
countries. Although diabetic retinopathy is considered a vascular disease, several reports …

[HTML][HTML] Diabetes changes the levels of ionotropic glutamate receptors in the rat retina

AR Santiago, JM Gaspar, FI Baptista… - Molecular …, 2009 - ncbi.nlm.nih.gov
Purpose Diabetic retinopathy (DR) is a leading cause of vision loss and blindness among
adults between the age 20 to 74. Changes in ionotropic glutamate receptor subunit …

[HTML][HTML] Deep brain stimulation for obesity: a review and future directions

DA Formolo, JM Gaspar, HM Melo, T Eichwald… - Frontiers in …, 2019 - frontiersin.org
The global prevalence of obesity has been steadily increasing. Although pharmacotherapy
and bariatric surgeries can be useful adjuvants in the treatment of morbid obesity, they may …

TGF-β1 down-regulation in the mediobasal hypothalamus attenuates hypothalamic inflammation and protects against diet-induced obesity

NF Mendes, JM Gaspar, JC Lima-Júnior, J Donato Jr… - Metabolism, 2018 - Elsevier
Background The consumption of large amounts of dietary fats induces hypothalamic inflammation
and impairs the function of the melanocortin system, leading to a defective regulation …

[HTML][HTML] Exercise improves the social and behavioral skills of children and adolescent with autism spectrum disorders

…, KMN Silva, HM Carvalho, JM Gaspar - Frontiers in …, 2022 - frontiersin.org
Background Currently, there is no standard treatment for Autism Spectrum Disorders (ASD),
but there are many ways to minimize the symptoms and maximize abilities. Some studies …