There is growing evidence to support a role for the ceramide-metabolizing enzyme,
glucosylceramide synthase (GCS), in resistance to a variety of chemotherapeutic agents. Whether …

Commonly used monolayer cancer cell cultures fail to provide a physiologically relevant
environment in terms of oxygen delivery. Here, we describe a three‐dimensional (3D) …

The platinum drugs cisplatin, carboplatin, and oxaliplatin are highly utilized in the clinic and
as a consequence have been extensively studied in the laboratory setting, sometimes by …

An accurate way to characterize the functional potential of a protein is to analyze recognized
protein domains encoded by the genes in a given group. The epsin N-terminal homology (…

Inside Cover: The cover image is based on the Original Research Article Spatial control of
oxygen delivery to 3D cultures alters cancer cell growth and gene expression by William J …

Early diagnosis of colorectal cancer (CRC) and access to optimal treatment achieves optimal
cancer outcomes. However, CRC survival inequalities persist with a lower survival rate for …

… We also observed a class E vps phenotype in group 3 strains, which were rescued by
genomic fragments containing VPS4. These defects are indicative of vacuolar protein sorting …

Scene 1, Canada: “Be open and friendly with each other”, the organisers of the BreakOut West
festival in Whitehorse in northern Canada urge, “the Wellness Room is waiting for you all …

Festivals have become one of the most significant and expansive elements in the popular
expression of cultural practices, as well as being applied instruments of cultural policy. Festival …

This is an original book, covering all the past areas of research anyone would need to know
about festivals and ‘event-based culture’. It is based on academic research but written in a …