User profiles for Joanna H. Maltbaek
 | Joanna MaltbaekUniversity of Washingon and University of California, Berkeley Verified email at uw.edu Cited by 500 |
ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP
JH Maltbaek, S Cambier, JM Snyder, DB Stetson - Immunity, 2022 - cell.com
The DNA sensor cyclic GMP-AMP synthase (cGAS) is important for antiviral and anti-tumor
immunity. cGAS generates cyclic GMP-AMP (cGAMP), a diffusible cyclic dinucleotide that …
immunity. cGAS generates cyclic GMP-AMP (cGAMP), a diffusible cyclic dinucleotide that …
Human DNA-PK activates a STING-independent DNA sensing pathway
K Burleigh, JH Maltbaek, S Cambier, R Green… - Science …, 2020 - science.org
Detection of intracellular DNA by the cGAS-STING pathway activates a type I interferon-mediated
innate immune response that protects from virus infection. Whether there are additional …
innate immune response that protects from virus infection. Whether there are additional …
PD-1/PD-L1 blockade enhances T-cell activity and antitumor efficacy of imatinib in gastrointestinal stromal tumors
…, MJ Beckman, BD Medina, JH Maltbaek… - Clinical Cancer …, 2017 - AACR
Purpose: Tyrosine kinase inhibitors are effective in gastrointestinal stromal tumors (GISTs)
but often are of transient benefit as resistance commonly develops. Immunotherapy, …
but often are of transient benefit as resistance commonly develops. Immunotherapy, …
Macrophages and CD8+ T Cells Mediate the Antitumor Efficacy of Combined CD40 Ligation and Imatinib Therapy in Gastrointestinal Stromal Tumors
…, JK Loo, J Santamaria-Barria, JH Maltbaek… - Cancer immunology …, 2018 - AACR
Tyrosine kinase inhibition of gastrointestinal stromal tumors (GIST) is effective but typically
culminates in resistance and is rarely curative. Immunotherapy has potential application to …
culminates in resistance and is rarely curative. Immunotherapy has potential application to …
Wnt/β-catenin signaling contributes to tumor malignancy and is targetable in gastrointestinal stromal tumor
…, F Rossi, MH Crawley, JK Loo, JH Maltbaek… - Molecular cancer …, 2017 - AACR
Gastrointestinal stromal tumor (GIST) is the most common type of sarcoma and usually harbors
either a KIT or PDGFRA mutation. However, the molecular basis for tumor malignancy is …
either a KIT or PDGFRA mutation. However, the molecular basis for tumor malignancy is …
Oncogenic kinase inhibition limits Batf3-dependent dendritic cell development and antitumor immunity
Gastrointestinal stromal tumor (GIST) is driven by an activating mutation in the KIT proto-oncogene.
Using a mouse model of GIST and human specimens, we show that intratumoral …
Using a mouse model of GIST and human specimens, we show that intratumoral …
The V654A second-site KIT mutation increases tumor oncogenesis and STAT activation in a mouse model of gastrointestinal stromal tumor
Gastrointestinal stromal tumor (GIST) is the most common human sarcoma and arises in the
gastrointestinal tract. Most GISTs are caused by activating mutations in the KIT receptor …
gastrointestinal tract. Most GISTs are caused by activating mutations in the KIT receptor …
[HTML][HTML] Csf1r or Mer inhibition delays liver regeneration via suppression of Kupffer cells
…, MH Crawley, BL Green, JK Loo, JH Maltbaek… - PloS one, 2019 - journals.plos.org
Introduction Murine Kupffer cells (KCs) comprise CD11b hi and F4/80 hi subsets. Tissue-resident
macrophages are known to express the tyrosine kinase receptors colony-stimulating …
macrophages are known to express the tyrosine kinase receptors colony-stimulating …
ABCC1/MRP1 exports cGAMP and modulates cGAS-dependent immunity
JH Maltbaek, JM Snyder, DB Stetson - bioRxiv, 2021 - biorxiv.org
The DNA sensor cyclic GMP-AMP synthase (cGAS) is important for antiviral and anti-tumor
immunity. cGAS generates cyclic GMP-AMP (cGAMP), a diffusible cyclic dinucleotide that …
immunity. cGAS generates cyclic GMP-AMP (cGAMP), a diffusible cyclic dinucleotide that …
[BOOK][B] Discovery of a Novel cGAMP Exporter that Regulates Innate Antiviral Immunity
J Maltbaek - 2022 - search.proquest.com
The DNA sensor cyclic GMP-AMP synthase (cGAS) is important for antiviral and anti-tumor
immunity. cGAS generates cyclic GMP-AMP (cGAMP), a diffusible cyclic dinucleotide that …
immunity. cGAS generates cyclic GMP-AMP (cGAMP), a diffusible cyclic dinucleotide that …