Background Restless legs syndrome is a prevalent chronic neurological disorder with
potentially severe mental and physical health consequences. Clearer understanding of the …

Immigration is an important force shaping the social structure, evolution, and genetics of
populations. A statistical method is presented that uses multilocus genotypes to identify …

Descriptions of human genetic variation given thirty years ago have held up well, considering
the substantial accrual of DNA sequence data in the interim. Most importantly, estimates of …

Starch consumption is a prominent characteristic of agricultural societies and hunter-gatherers
in arid environments. In contrast, rainforest and circum-arctic hunter-gatherers and some …

A debate has recently arisen over the use of racial classification in medicine and biomedical
research. In particular, with the completion of a rough draft of the human genome, some …

Over the past 500 years, North America has been the site of ongoing mixing of Native
Americans, European settlers, and Africans (brought largely by the trans-Atlantic slave trade), …

Although the causes of Parkinson's disease (PD) are thought to be primarily environmental,
recent studies suggest that a number of genes influence susceptibility. Using targeted case …

Africa is inferred to be the continent of origin for all modern human populations, but the details
of human prehistory and evolution in Africa remain largely obscure owing to the complex …

Accuracy of evolutionary analysis of populations within a species requires the testing of a
large number of genetic polymorphisms belonging to many loci. We report here a …

Myopia, or nearsightedness, is the most common eye disorder, resulting primarily from excess
elongation of the eye. The etiology of myopia, although known to be complex, is poorly …