Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …

More than 800 published genetic association studies have implicated dozens of potential
risk loci in Parkinson's disease (PD). To facilitate the interpretation of these findings, we have …

Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic
architecture or its genetic relationship with other disorders. To discover loci associated …

Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology.
Understanding the genetic factors contributing to the shared and disorder-specific symptoms …

Background Lithium is a first-line treatment in bipolar disorder, but individual response is
variable. Previous studies have suggested that lithium response is a heritable trait. However, …

Objective Social determinants of health (SDoH) are nonclinical dispositions that impact
patient health risks and clinical outcomes. Leveraging SDoH in clinical decision-making can …

Bipolar disorder (BD) is a genetically complex mental illness characterized by severe
oscillations of mood and behaviour. Genome-wide association studies (GWAS) have identified …

Objective: More than 90% of people who attempt suicide have a psychiatric diagnosis;
however, twin and family studies suggest that the genetic etiology of suicide attempt is partially …

Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts,
which occur far more frequently, are a major source of disability and social and economic …

Objective To compare the efficacy and discontinuation of augmentation agents in adult
patients with treatment-resistant depression (TRD). We conducted a systematic review and …