The extracellular matrix (ECM) is a salient feature of all solid tissues within the body. This
complex, acellular entity is composed of hundreds of individual molecules whose assembly, …

The cellular and molecular basis of stromal cell recruitment, activation and crosstalk in
carcinomas is poorly understood, limiting the development of targeted anti-stromal therapies. In …

The tumour stroma, and in particular the extracellular matrix (ECM), is a salient feature of solid
tumours that plays a crucial role in shaping their progression. Many desmoplastic tumours …

The lysyl oxidase family represents a promising target in stromal targeting of solid tumors
due to the importance of this family in crosslinking and stabilizing fibrillar collagens and its …

In prostate cancer, cancer-associated fibroblasts (CAF) exhibit contrasting biological
properties to non-malignant prostate fibroblasts (NPF) and promote tumorigenesis. Resolving …

The extracellular matrix (ECM) is a master regulator of cellular phenotype and behaviour. It
plays a crucial role in both normal tissue homeostasis and complex diseases such as cancer. …

Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic, chemoresistant malignancy
and is characterized by a dense, desmoplastic stroma that modulates PDAC progression. …

Understanding the underlying mechanisms of migration and metastasis is a key focus of
cancer research. There is an urgent need to develop in vitro 3D tumor models that can mimic …

In recent decades, the role of tumor biomechanics on cancer cell behavior at the primary site
has been increasingly appreciated. However, the effect of primary tumor biomechanics on …

To fully investigate cellular responses to stimuli and perturbations within tissues, it is
essential to replicate the complex molecular interactions within the local microenvironment of …