The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress
Mutations in BRCA1 are associated with a high risk of breast and ovarian cancer. BRCA1
participates in the DNA damage response and acts as a ubiquitin ligase. However, its …
participates in the DNA damage response and acts as a ubiquitin ligase. However, its …
[HTML][HTML] Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer
…, JR Morris, SM Moss, P Mullan, R Natrajan… - Breast Cancer …, 2013 - Springer
Introduction Breast cancer remains a significant scientific, clinical and societal challenge.
This gap analysis has reviewed and critically assessed enduring issues and new challenges …
This gap analysis has reviewed and critically assessed enduring issues and new challenges …
BRCA1: BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair
JR Morris, E Solomon - Human molecular genetics, 2004 - academic.oup.com
The N-terminus of the BRCA1 protein bears a RING finger domain that functions as an E3
ubiquitin ligase in vitro where it is able to catalyse the synthesis of monoubiquitin and …
ubiquitin ligase in vitro where it is able to catalyse the synthesis of monoubiquitin and …
Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection
The opposing activities of 53BP1 and BRCA1 influence pathway choice in DNA double-strand-break
repair. How BRCA1 counteracts the inhibitory effect of 53BP1 on DNA resection …
repair. How BRCA1 counteracts the inhibitory effect of 53BP1 on DNA resection …
[PDF][PDF] BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance
…, M Pieterse, A Catteau, P Green, E Solomon, JR Morris… - Cancer cell, 2011 - cell.com
Hereditary breast cancers are frequently caused by germline BRCA1 mutations. The BRCA1
C61G mutation in the BRCA1 RING domain is a common pathogenic missense variant, …
C61G mutation in the BRCA1 RING domain is a common pathogenic missense variant, …
The proteasomal de‐ubiquitinating enzyme POH1 promotes the double‐strand DNA break response
The regulation of Ubiquitin (Ub) conjugates generated by the complex network of proteins that
promote the mammalian DNA double‐strand break (DSB) response is not fully understood…
promote the mammalian DNA double‐strand break (DSB) response is not fully understood…
Isomerization of BRCA1–BARD1 promotes replication fork protection
The integrity of genomes is constantly threatened by problems encountered by the replication
fork. BRCA1, BRCA2 and a subset of Fanconi anaemia proteins protect stalled replication …
fork. BRCA1, BRCA2 and a subset of Fanconi anaemia proteins protect stalled replication …
BRCA1 methylation: a significant role in tumour development?
A Catteau, JR Morris - Seminars in cancer biology, 2002 - Elsevier
Cancer is a multistep process resulting from an accumulation of genetic mutations leading
to dysfunction of critical genes, including tumour suppressor genes. Epigenetic changes are …
to dysfunction of critical genes, including tumour suppressor genes. Epigenetic changes are …
The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair
…, HR Stone, D Weekes, KJ Lawrence, JR Morris - EMBO …, 2013 - embopress.org
SUMO conjugation is known to occur in response to double‐stranded DNA breaks in
mammalian cells, but whether SUMO deconjugation has a role remains unclear. Here, we show …
mammalian cells, but whether SUMO deconjugation has a role remains unclear. Here, we show …
The Forkhead Box M1 protein regulates BRIP1 expression and DNA damage repair in epirubicin treatment
LJ Monteiro, P Khongkow, M Kongsema, JR Morris… - Oncogene, 2013 - nature.com
FOXM1 is implicated in genotoxic drug resistance but its role and mechanism of action
remain unclear. Here, we establish that γH2AX foci, indicative of DNA double-strand breaks (…
remain unclear. Here, we establish that γH2AX foci, indicative of DNA double-strand breaks (…