Activation and disruption of Wnt/β-catenin signaling both result in cartilage breakdown via
unknown mechanisms. Here we show that both WNT-3A and the Wnt inhibitor DKK1 induced …

Objective Both excessive and insufficient activation of WNT signalling results in cartilage
breakdown and osteoarthritis. WNT16 is upregulated in the articular cartilage following injury …

Background It is important to identify trends in deliberate self-harm because of potential
links both with complex mental health problems and with suicide itself, and because of its …

CRISPR-Cas9–mediated homology-directed DNA repair is the method of choice for precise
gene editing in a wide range of model organisms, including mouse and human. Broad use …

Objectives Osteophytes are highly prevalent in osteoarthritis (OA) and are associated with
pain and functional disability. These pathological outgrowths of cartilage and bone typically …

Objective ELR+ CXC chemokines are heparin-binding cytokines signalling through the CXCR1
and CXCR2 receptors. ELR+ CXC chemokines have been associated with inflammatory …

Synovial joints are unique functional elements of the body and provide the ability for
locomotion and for physical interaction with the environment. They are composed of different …

The progressive destruction of articular cartilage is a hallmark of RA, a systemic autoimmune
disease predominantly affecting synovial joints that often results in severe disability. …

Osteoarthritis (OA) is characterized by cartilage degradation that is induced by inflammation.
Sterile inflammation can be caused by damage-associated molecular patterns that are …

Highlights • Cartilage breakdown is the disabling outcome of rheumatic diseases. • Inflammation,
chondrocyte phenotype and homeostatic mechanisms have recently been the focus of …