Renal hypoplasia, defined as abnormally small kidneys with normal morphology and reduced
nephron number, is a common cause of pediatric renal failure and adult-onset disease. …

Vertebrate sensory organs arise from epithelial thickenings called placodes. Along with neural
crest cells, cranial placodes are considered ectodermal novelties that drove evolution of …

Objectives Osteophytes are highly prevalent in osteoarthritis (OA) and are associated with
pain and functional disability. These pathological outgrowths of cartilage and bone typically …

10.7554/eLife.42736.001 Much of the vertebrate skeleton develops from cartilage templates
that are progressively remodeled into bone. Lineage tracing studies in mouse suggest that …

The cranial neural crest generates a huge diversity of derivatives, including the bulk of
connective and skeletal tissues of the vertebrate head. How neural crest cells acquire such …

10.7554/eLife.16415.001 Synovial joints are the lubricated connections between the bones
of our body that are commonly affected in arthritis. It is assumed that synovial joints first …

The regulated expansion of chondrocytes within growth plates and joints ensures proper
skeletal development through adulthood. Mutations in the transcription factor NKX3.2 underlie …

The integrin-linked kinase (ILK), pinch and parvin ternary complex connects the cytoplasmic
tails of β1 integrins to the actin cytoskeleton. We recently showed that constitutive …

Congenital inner ear malformations affecting both the osseous and membranous labyrinth
can have a devastating impact on hearing and language development. With the exception of …

The poor intrinsic repair capacity of mammalian joint cartilage likely contributes to the high
incidence of arthritis worldwide. Adult zebrafish can regenerate many structures that show …