A unique chromatin signature uncovers early developmental enhancers in humans
…, T Swigut, SA Brugmann, RA Flynn, J Wysocka - Nature, 2011 - nature.com
Cell-fate transitions involve the integration of genomic information encoded by regulatory
elements, such as enhancers, with the cellular environment 1 , 2 . However, identification of …
elements, such as enhancers, with the cellular environment 1 , 2 . However, identification of …
Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells
Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections, and comprise
nearly 8% of the human genome 1 . The most recently acquired human ERV is HERVK(HML…
nearly 8% of the human genome 1 . The most recently acquired human ERV is HERVK(HML…
[HTML][HTML] Enhancer divergence and cis-regulatory evolution in the human and chimp neural crest
cis-regulatory changes play a central role in morphological divergence, yet the regulatory
principles underlying emergence of human traits remain poorly understood. Here, we use …
principles underlying emergence of human traits remain poorly understood. Here, we use …
A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling
Lysine methylation of histones is recognized as an important component of an epigenetic
indexing system demarcating transcriptionally active and inactive chromatin domains. …
indexing system demarcating transcriptionally active and inactive chromatin domains. …
[PDF][PDF] Modification of enhancer chromatin: what, how, and why?
E Calo, J Wysocka - Molecular cell, 2013 - cell.com
Emergence of form and function during embryogenesis arises in large part through cell-type-
and cell-state-specific variation in gene expression patterns, mediated by specialized cis-…
and cell-state-specific variation in gene expression patterns, mediated by specialized cis-…
[PDF][PDF] Epigenomic annotation of enhancers predicts transcriptional regulators of human neural crest
…, S Prescott, SA Brugmann, T Swigut, J Wysocka - Cell stem cell, 2012 - cell.com
Neural crest cells (NCC) are a transient, embryonic cell population characterized by
unusual migratory ability and developmental plasticity. To annotate and characterize cis-regulatory …
unusual migratory ability and developmental plasticity. To annotate and characterize cis-regulatory …
[HTML][HTML] H3K27 demethylases, at long last
T Swigut, J Wysocka - Cell, 2007 - cell.com
Methylation of lysine 27 on histone H3 (H3K27me) by the Polycomb complex (PRC2) proteins
is associated with gene silencing in many developmental processes. A cluster of recent …
is associated with gene silencing in many developmental processes. A cluster of recent …
A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression
…, A Protacio, RA Flynn, RA Gupta, J Wysocka… - Nature, 2011 - nature.com
The genome is extensively transcribed into long intergenic noncoding RNAs (lincRNAs),
many of which are implicated in gene silencing 1 , 2 . Potential roles of lincRNAs in gene …
many of which are implicated in gene silencing 1 , 2 . Potential roles of lincRNAs in gene …
[HTML][HTML] Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification
We report the identification of 67 previously undescribed histone modifications, increasing
the current number of known histone marks by about 70%. We further investigated one of the …
the current number of known histone marks by about 70%. We further investigated one of the …
[HTML][HTML] Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark
AJ Ruthenburg, CD Allis, J Wysocka - Molecular cell, 2007 - cell.com
Cells employ elaborate mechanisms to introduce structural and chemical variation into chromatin.
Here, we focus on one such element of variation: methylation of lysine 4 in histone H3 (…
Here, we focus on one such element of variation: methylation of lysine 4 in histone H3 (…