The pharmaceutical industry is continuing to face high research and development (R&D)
costs and low overall success rates of clinical compounds during drug development. There is …

Importance Given minority patients’ unequal access to quality care, patient activation and
self-management strategies have been suggested as a promising approach to improving …

Animal studies in pharmaceutical drug discovery are common in preclinical research for
compound evaluation before progression into human clinical trials. However, high rates of drug …

Research collaboration in “real world” practice settings may enhance the meaningfulness of
the findings and reduce barriers to implementation of novel intervention strategies. This …

The author recalls GLOVER'S English report on the fall in incidence of rheumatic fever [this
Bulletin, 1943, v. 18, 1014]. In Australia apparently such a fall has not been noted, and the …

This chapter considers what is needed for the design and conduct of animal experiments to
accord with Directive 2010/63/EU, and has various sections to help researchers carry out …

HIV disease has been known to affect both homosexual men and injection drug users since
the early 1980s; however, for a long time society viewed it as a gay man's disease (Shilts, …

The author points out certain similarities between serum sickness and rheumatic fever, and
quotes two reports of patients who developed earditis after serum, sickness. She also recalls, …

BackgroundThe ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines
are widely endorsed but compliance is limited. We sought to determine whether journal-…

The pharmaceutical industry is facing unprecedented challenges as the cost of developing
new drugs has reached unsustainable levels, fueled in large parts by a high attrition rate in …