INTRODUCTION Protein-protein interactions play critical roles in biology, but the structures
of many eukaryotic protein complexes are unknown, and there are likely many interactions …

DNA damage recognition by the nucleotide excision repair pathway requires an initial step
identifying helical distortions in the DNA and a proofreading step verifying the presence of a …

The molybdenum cofactor is part of the active site of all molybdenum-dependent enzymes 1
, except nitrogenase. The molybdenum cofactor consists of molybdopterin, a phosphorylated …

Nucleotide excision repair (NER) has allowed bacteria to flourish in many different niches
around the globe that inflict harsh environmental damage to their genetic material. NER is …

G-quadruplex (G4) DNA, an alternate structure formed by Hoogsteen hydrogen bonds
between guanines in G-rich sequences, threatens genomic stability by perturbing normal DNA …

The XPD protein is a vital subunit of the general transcription factor TFIIH which is not only
involved in transcription but is also an essential component of the eukaryotic nucleotide …

MYC genes have both essential roles during normal development and exert oncogenic
functions during tumorigenesis. Expression of a dominant-negative allele of MYC, termed …

The eukaryotic XPD helicase is an essential subunit of TFIIH involved in both transcription
and nucleotide excision repair (NER). Mutations in human XPD are associated with several …

Small nuclear ribonucleoproteins (snRNPs) represent key constituents of major and minor
spliceosomes. snRNPs contain a common core, composed of seven Sm proteins bound to …

Death-associated protein kinase (DAPK) provides a model for calcium-bound calmodulin (CaM)–dependent
protein kinases (CaMKs). Here, we report the crystal structure of the binary …