Focal segmental glomerulosclerosis (FSGS) is a cause of proteinuric kidney disease,
compromising both native and transplanted kidneys. Treatment is limited because of a complex …

Focal segmental glomerulosclerosis (FSGS) is a glomerular disease characterized by
proteinuria, progression to end-stage renal disease, and recurrence of proteinuria after kidney …

Injury to podocytes and their slit diaphragms typically leads to marked proteinuria. Mutations
in the TRPC6 gene that codes for a slit diaphragm–associated, cation-permeable ion …

ABSTRACT. Recent molecular insights have established the podocyte as a key component
of the glomerular filtration barrier, and hence an important common pathway in proteinuric …

The immunosuppressive action of the calcineurin inhibitor cyclosporine A (CsA) stems from
the inhibition of nuclear factor of activated T cells (NFAT) signaling in T cells. CsA is also …

Mature podocytes are among the most complex differentiated cells and possess a highly
branched array of foot processes that are essential to glomerular filtration in the kidney. Such …

Progressive kidney failure is a genetically and clinically heterogeneous group of disorders.
Podocyte foot processes and the interposed glomerular slit diaphragm are essential …

Importance The US is currently an epicenter of the coronavirus disease 2019 (COVID-19)
pandemic, yet few national data are available on patient characteristics, treatment, and …

NPHS2 was recently identified as a gene whose mutations cause autosomal recessive
steroid-resistant nephrotic syndrome. Its product, podocin, is a new member of the stomatin family…

Importance Therapies that improve survival in critically ill patients with coronavirus disease
2019 (COVID-19) are needed. Tocilizumab, a monoclonal antibody against the interleukin 6 …