[PDF][PDF] SARS-CoV-2 genomic surveillance identifies naturally occurring truncation of ORF7a that limits immune suppression
Over 950,000 whole-genome sequences of severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) have been determined for viruses isolated from around the world. These …
2 (SARS-CoV-2) have been determined for viruses isolated from around the world. These …
[PDF][PDF] Intrinsic signal amplification by type III CRISPR-Cas systems provides a sequence-specific SARS-CoV-2 diagnostic
…, T Wiegand, RA Wilkinson, DT Snyder, JF Hedges… - Cell Reports …, 2021 - cell.com
There is an urgent need for inexpensive new technologies that enable fast, reliable, and
scalable detection of viruses. Here, we repurpose the type III CRISPR-Cas system for sensitive …
scalable detection of viruses. Here, we repurpose the type III CRISPR-Cas system for sensitive …
Comparative biology of γδ T cell function in humans, mice, and domestic animals
J Holderness, JF Hedges, A Ramstead… - Annu. Rev. Anim …, 2013 - annualreviews.org
γδ T cells are a functionally heterogeneous population and contribute to many early immune
responses. The majority of their activity is described in humans and mice, but the immune …
responses. The majority of their activity is described in humans and mice, but the immune …
γδ T cells respond directly to pathogen-associated molecular patterns
JF Hedges, KJ Lubick, MA Jutila - The Journal of Immunology, 2005 - journals.aai.org
γδ T cells recognize unprocessed or non-peptide Ags, respond rapidly to infection, and localize
to mucosal surfaces. We have hypothesized that the innate functions of γδ T cells may be …
to mucosal surfaces. We have hypothesized that the innate functions of γδ T cells may be …
[HTML][HTML] Polysaccharides isolated from Acai fruit induce innate immune responses
…, B Freedman, LN Kirpotina, MT Quinn, JF Hedges… - PloS one, 2011 - journals.plos.org
The Açaí (Acai) fruit is a popular nutritional supplement that purportedly enhances immune
system function. These anecdotal claims are supported by limited studies describing immune …
system function. These anecdotal claims are supported by limited studies describing immune …
[HTML][HTML] Effect of inactivation methods on SARS-CoV-2 virion protein and structure
EK Loveday, KS Hain, I Kochetkova, JF Hedges… - Viruses, 2021 - mdpi.com
The risk posed by Severe Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2)
dictates that live-virus research is conducted in a biosafety level 3 (BSL3) facility. Working with …
dictates that live-virus research is conducted in a biosafety level 3 (BSL3) facility. Working with …
Differential mRNA expression in circulating γδ T lymphocyte subsets defines unique tissue-specific functions
JF Hedges, D Cockrell, L Jackiw… - Journal of Leucocyte …, 2003 - academic.oup.com
To elucidate the functions of circulating γδ T cells, in the absence of antigen stimulation, the
differential gene expression of two circulating γδ T cell subsets was analyzed. The two …
differential gene expression of two circulating γδ T cell subsets was analyzed. The two …
Genetic divergence with emergence of novel phenotypic variants of equine arteritis virus during persistent infection of stallions
JF Hedges, UBR Balasuriya, PJ Timoney… - Journal of …, 1999 - Am Soc Microbiol
The persistently infected carrier stallion is the critical natural reservoir of equine arteritis
virus (EAV), as venereal infection of mares frequently occurs after breeding to such stallions. …
virus (EAV), as venereal infection of mares frequently occurs after breeding to such stallions. …
Alphavirus replicon particles expressing the two major envelope proteins of equine arteritis virus induce high level protection against challenge with virulent virus in …
…, NL Davis, HM Wagner, PJ Hullinger, JF Hedges… - Vaccine, 2002 - Elsevier
Replicon particles derived from a vaccine strain of Venezuelan equine encephalitis (VEE)
virus were used as vectors for expression in vivo of the major envelope proteins (G L and M) of …
virus were used as vectors for expression in vivo of the major envelope proteins (G L and M) of …
Serial analysis of gene expression in circulating γδ T cell subsets defines distinct immunoregulatory phenotypes and unexpected gene expression profiles
N Meissner, J Radke, JF Hedges, M White… - The Journal of …, 2003 - journals.aai.org
Gene expression profiles were compared in circulating bovine GD3. 5+(CD8−) and GD3. 5−(predominantly
CD8+) γδ T cells using serial analysis of gene expression (SAGE). …
CD8+) γδ T cells using serial analysis of gene expression (SAGE). …