Genetic disorders of the Ras/MAPK pathway, termed RASopathies, produce numerous
abnormalities, including cutaneous keratodermas. The desmosomal cadherin, desmoglein-1 (…

Desmosomes are intercellular junctions that mediate cell–cell adhesion and anchor the
intermediate filament network to the plasma membrane, providing mechanical resilience to …

Resistance of Cutibacterium acnes to topical antibiotics historically used to treat acne (topical
erythromycin and clindamycin and, more recently, topical azithromycin and clarithromycin) …

Prolonged broad-spectrum antibiotic use is more likely to induce bacterial resistance and
dysbiosis of skin and gut microflora. First and second-generation tetracycline-class antibiotics …

Desmoglein 1 (Dsg1) is a cadherin restricted to stratified tissues of terrestrial vertebrates,
which serve as essential physical and immune barriers. Dsg1 loss-of-function mutations in …

The epidermis is the first line of defense against ultraviolet (UV) light from the sun. Keratinocytes
and melanocytes respond to UV exposure by eliciting a tanning response dependent in …

Epidermal structure is damaged by exposure to UV light, but the molecular mechanisms
governing structural repair are largely unknown. UVB (290–320 nm wavelengths) exposure …

Modifications associated with urban infrastructure directly impact soil properties. In particular,
soil bulk density, microbial biomass and activity, and organic matter are impacted by …

Designer nucleases have gained widespread attention for their ability to precisely modify
genomic DNA in a programmable manner. These genome-editing nucleases make double-…

Melanoma is an aggressive cancer typically arising from transformation of melanocytes
residing in the basal layer of the epidermis, where they are in direct contact with surrounding …