Hebb's rule (1949) states that learning and memory are based on modifications of synaptic
strength among neurons that are simultaneously active. This implies that enhanced synaptic …

We produced CA1-specific NMDA receptor 1 subunit-knockout (CA1-KO) mice to determine
the NMDA receptor dependence of nonspatial memory formation and of experience-induced …

Using the phage P1–derived Cre/loxP recombination system, we have developed a method
to create mice in which the deletion (knockout) of virtually any gene of interest is restricted to …

An enriched environment is known to promote structural changes in the brain and to enhance
learning and memory performance in rodents [Hebb, DO (1947) Am. Psychol. 2, 306–307]. …

We have produced a mouse strain in which the deletion of the NMDAR1 gene is restricted
to the CA1 pyramidal cells of the hippocampus by using a new and general method that …

Protein kinases have proved to be largely resistant to the design of highly specific inhibitors,
even with the aid of combinatorial chemistry 1 . The lack of these reagents has complicated …

To investigate the role of synaptic plasticity in the place-specific firing of the hippocampus,
we have applied multiple electrode recording techniques to freely behaving mice with a CA1 …

The hippocampal CA1 region is crucial for converting new memories into long-term
memories, a process believed to continue for week(s) after initial learning. By developing an …

To examine the in vivo function of presenilin-1 (PS1), we selectively deleted the PS1 gene
in excitatory neurons of the adult mouse forebrain. These conditional knockout mice were …

The N-methyl-D-aspartate (NMDA) receptor (NMDAR) is the predominant molecular device
for controlling synaptic plasticity and memory function. 1 Thus, an understanding of the …