Vertebrates have a unique 3D body shape in which correct tissue and organ shape and
alignment are essential for function. For example, vision requires the lens to be centred in the …

The optic vesicle comprises a pool of bi-potential progenitor cells from which the retinal
pigment epithelium (RPE) and neural retina fates segregate during ocular morphogenesis. …

This chapter provides an overview of the early developmental origins of six ocular tissues:
the cornea, lens, ciliary body, iris, neural retina, and retina pigment epithelium. Many of these …

To gain insights into the cellular mechanisms of neurogenesis, we analyzed retinal
neuroepithelia deficient for Llgl1, a protein implicated in apicobasal cell polarity, asymmetric cell …

To investigate the role of Hippo pathway signaling during vertebrate development transgenic
zebrafish lines were generated and validated to dynamically monitor and manipulate Yap/…

The retinal ganglion cell (RGC) competence factor ATOH7 is dynamically expressed during
retinal histogenesis. ATOH7 transcription is controlled by a promoter-adjacent primary …

The Atoh7 transcription factor catalyzes the rate-limiting step in the specification of retinal
ganglion cells (RGCs). As a tool to study vertebrate retinal development, we validate an …

Balancing the rate of differentiation and proliferation in developing tissues is essential to
produce organs of robust size and composition. Although many molecular regulators have been …

In vertebrate retinal progenitor cells, the proneural factor Atoh7 exhibits a dynamic tissue and
cellular expression pattern. Although the resulting Atoh7 retinal lineage contains all seven …

Interkinetic nuclear migration (IKNM) is the process in which pseudostratified epithelial
nuclei oscillate from the apical to basal surface and in phase with the mitotic cycle. In the …