We have identified a homolog of the mammalian p53 tumor suppressor protein in the nematode
Caenorhabditis elegans that is expressed ubiquitously in embryos. The gene encoding …

We have devised a genetic selection for mutant yeast cells that fail to properly deliver the
vacuolar glycoprotein CPY to the lysosome-like vacuole. This has allowed us to identify …

The proteinase A structural gene of Saccharomyces cerevisiae was cloned by using an
immunological screening procedure that allows detection of yeast cells which are aberrantly …

To further our studies of protein sorting and biogenesis of the lysosome‐like vacuole in yeast,
we have isolated spontaneous mutations in 11 new VPL complementation groups, as well …

Members of the MKLP1 subfamily of kinesin motor proteins localize to the equatorial region
of the spindle midzone and are capable of bundling antiparallel microtubules in vitro. …

The endoderm in the nematode Caenorhabditis elegans is clonally derived from the E founder
cell. We identified a single genomic region (the endoderm-determining region, or EDR) …

We have isolated c&-acting mutations in the gene encoding the yeast vacuolar protein
carboxypeptidase Y (CPY) that result in missorting and aberrant secretion of up to 95% of newly …

The endoderm and much of the mesoderm arise from the EMS cell in the four-cell C. elegans
embryo. We report that the MED-1 and -2 GATA factors specify the entire fate of EMS, …

The nematode Caenorhabditis elegans is a triploblastic ecdysozoan, which, although it
contains too few cells during embryogenesis to create discernible germ “layers,” deploys similar …

The C. elegans epidermis is a simple epithelium comprised of three major cell types, the
seam, syncytial and P cells. While specification of all major epidermal cells is known to require …