A challenge in the clinical adoption of cell-free DNA (cfDNA) liquid biopsies for cancer care
is their high cost compared to potential reimbursement. The most common approach used in …

We demonstrate a unique parameter for biomolecule separation that results from the nonlinear
response of long, charged polymers to electrophoretic fields and apply it to extraction and …

We present a novel means of transporting molecules in solution by applying a zero‐time‐average
alternating motive force to the molecules, and perturbing the molecular drag …

Forensic crime scene sample analysis, by its nature, often deals with samples in which there
are low amounts of nucleic acids, on substrates that often lead to inhibition of subsequent …

Rare mutations in cell populations are known to be hallmarks of many diseases and cancers.
Similarly, differential DNA methylation patterns arise in rare cell populations with …

Targeted Next Generation Sequencing (NGS) is being adopted increasingly broadly in many
research, commercial and clinical settings. Currently used target capture methods, however…

Molecular manipulation and separation techniques form the building blocks for much of
fundamental science, yet many separation challenges still remain, in fields as diverse as …

DISCUSSION Pulsed field gel electrophoresis (PFGE) analysis of purified DNA indicates
that the SCODA method typically yields DNA between 23 kb and 194 kb in length (see Fig. 1). …

13 A challenge in the clinical adoption of cell-free DNA (cfDNA) liquid biopsies for cancer 14
care is their high cost compared to potential reimbursement. The most common approach …

We have demonstrated a novel somatic mutation enrichment methodology demonstrating
multiplexed detection of tumor mutations in plasma with sensitivity as low as 0.01 …