Deep brain stimulation (DBS) has provided remarkable benefits for people with a variety of
neurologic conditions. Stimulation of the ventral intermediate nucleus of the thalamus can …

We investigated swallowing abnormalities in patients with Parkinson's disease, the relationship
between these abnormalities and general parkinsonian signs, as well as the response to …

We conducted a meta-analysis of Parkinson's disease genome-wide association studies
using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six …

Background Parkinson disease (PD) is a degenerative neurological disorder for which no
treatment has been shown to slow the progression. Objective To determine whether a range of …

Surgicalxtant methods for anatomical localization within a physiological image are inadequate
for precise regional correlations between anatomy and physiology. We have developed a …

Classical accounts of the pathophysiology of Parkinson’s disease have emphasized
degeneration of dopaminergic nigrostriatal neurons with consequent dysfunction of cortico–striatal–…

Autosomal-recessive early-onset parkinsonism is clinically and genetically heterogeneous.
The genetic causes of approximately 50% of autosomal-recessive early-onset forms of …

Mutations in leucine-rich repeat kinase 2 (LRRK2) cause inherited Parkinson disease (PD),
and common variants around LRRK2 are a risk factor for sporadic PD. Using protein–protein …

Importance Coenzyme Q10 (CoQ10), an antioxidant that supports mitochondrial function, has
been shown in preclinical Parkinson disease (PD) models to reduce the loss of dopamine …

… Given the scientific, regulatory, and clinical implications of the accelerated FDA approval of
aducanumab for Alzheimer’s disease, it’s essential to consider beta-amyloid’s suitability as a …